Headache Registration and Followup Initiated by Tongji Hospital, HUST

This research is a multi-center, prospective observational study focusing on headache patients, initiated by Tongji Hospital affiliated to Tongji Medical College of Huazhong University of Science and Technology (HUST). The study encompasses several key components:

• Study Population and Data Collection:
• Target enrollment: 50,000 with clinical data, and 1,500 headache patients with biological specimen collection
• Recruitment site: Department of Neurology, Tongji Hospital; cooperate headache centers around China

Initial data collection includes:

• Epidemiological information
• Clinical data
• Imaging data
• Questionnaire responses
• 5ml venous blood samples

Follow-up Protocol:

Duration: 10 years Follow-up intervals: face-to-face interviews during the first three months and telephone follow-ups by years

Monitoring parameters:

• Medication, clinical efficacy
• Headache-related history records
• Adverse reactions

Technical Framework:

• Database Development:

Establishment of several integrated databases:

Clinical database (epidemiological data, imaging, and EEG assessments) Biological sample repository Multi-omics bioinformatics database

• Advanced Technical Applications:

Implementation of cutting-edge biotechnologies:

Immunotherapy approaches Multi-omics detection technologies Big data bioinformatics analysis

• Analytical Components:

Development of machine learning algorithms Drug target evaluation systems Clinical efficacy monitoring models Outcome prediction models

Research Objectives Implementation:

Construction of molecular interaction networks related to headache Development of AI-based drug target assessment tools Establishment of standardized follow-up evaluation systems Validation of potential drug targets Creation of a comprehensive data-sharing platform

Expected Outcomes:

Enhanced understanding of headache pathogenesis Improved diagnostic capabilities Identification of novel therapeutic targets Development of personalized treatment approaches Establishment of a standardized evaluation system for clinical outcomes This detailed research framework aims to create a comprehensive precision medicine system for headache diagnosis and treatment, ultimately contributing to breakthrough advances in headache prevention and treatment strategies.

Inclusion criteria

• Meeting the diagnostic criteria for headache classification according to the International Classification of Headache Disorders 3rd edition (ICHD-3, 2018) Age between 6-70 years Voluntary participation with consent Good compliance with follow-up and questionnaire surveys

Exclusion criteria

• Complex headache etiology, e.g., presence of ≥3 distinct factors causing headache Presence of severe systemic diseases or life expectancy less than 10 years Significant cognitive or psychiatric issues that prevent completion of questionnaire follow-ups and clinical assessments