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Completed

NCT Number: NCT01061008

Handgrip Exercise for Arteriovenous Fistula Maturation

The purpose of this study is to investigate whether post operative progressive forearm exercise is effective in improving arteriovenous fistula maturation in chronic kidney disease patients.

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Key information

Conditions

Chronic Kidney Disease Arteriovenous Fistula Arteriovenous Malformations Behavior Cardiovascular Abnormalities Cardiovascular Diseases Chronic Disease Congenital Abnormalities Congenital, Hereditary, and Neonatal Diseases and Abnormalities Disease Attributes Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Fistula Kidney Diseases Male Urogenital Diseases Motor Activity Pathologic Processes Pathological Conditions, Anatomical Pathological Conditions, Signs and Symptoms Renal Insufficiency Renal Insufficiency, Chronic Urogenital Diseases Urologic Diseases Vascular Diseases Vascular Fistula Vascular Malformations

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Renal unit, Ysbyty Gwynedd, North West Wales NHS Trust

Bangor, Gwynedd, LL57 2PW, United Kingdom

About this study

The arteriovenous fistula is considered to be the gold standard form of access for haemodialysis patients, however only 37% of haemodialysis patients have this form of access. A possible explanation for this could be the high fistula failure rate due to the lack of maturation. Therefore interventions aimed at enhancing fistula maturation are warranted. One such intervention could be forearm exercise, however this recommendation is not evidence based. Therefore, the purpose of this study is to investigate whether a program of post operative progressive hand grip exercise can improve fistula maturation.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Stage 4-5 chronic kidney disease, attending for arteriovenous fistula creation in forearm

Exclusion criteria

  • Are under the age of 18years;
  • Not able to exercise forearm safely (as decided by the patients consultant)
  • Have any other uncontrolled medical condition
  • Unable to withstand transiently raised systolic blood pressure by 35 mmHg and diastolic by 25 mmHg
  • Or are unable to give consent

Treatment and study plan

Post operative progressive handgrip exercise

Other

As soon as possible post operation the patient will commence an eight week progressive handgrip training intervention

Treatment as Usual

Other

Continue routine care, with removal of exercise information given to patients(if anye.g. do not give out squeeze balls)

Primary outcomes

  1. Venous Diameter.

    Time frame: 3 months

    Measurements were made using duplex ultrasonagraphy. Measurements were made at predetermined distances 5 to 10 cm proximal to the anastomosis (dependent on wound dressings and turbulent flow around the anastomosis). The scanning position for each patient was traced using transparent sheets which allowed analogous measurement positions for all scans. Cross sectional vascular diameter measurements were made using conventional grey scale B Mode imaging. Diameters were measured from the inner edges of the vascular wall (Wiese & Nonnast-Daniel, 2004).

Secondary outcomes

  1. Maximum Handgrip Strength

    Time frame: 3 months

  2. Handgrip Endurance

    Time frame: 3 months

  3. Forearm Muscle Cross Sectional Area

    Time frame: 3 months

Sponsors and collaborators

Lead sponsor

Bangor University

Other

Collaborators

  • Betsi Cadwaladr University Health Board

Registry information

Official study title

The Effects of Progressive Handgrip Exercise Training on Arteriovenous Fistula Maturation in Chronic Kidney Disease

Important dates

Study start
2008
Primary completion
2012
Study completion
2012
First posted
Feb 2, 2010
Registry last updated
Jul 15, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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