Recruiting

NCT Number: NCT03934957

Hamburg City Health Study - a German Cohort Study

The Hamburg City Health Study (HCHS) is a large, prospective, long-term, population-based cohort study and a unique research platform and network to obtain substantial knowledge about several risk and prognostic factors in major chronic diseases.

Recruiting

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Key information

Conditions

Coronary Heart Disease Body Weight Brain Diseases Cancer Cardiovascular Diseases Central Nervous System Diseases Cerebrovascular Disorders Coronary Disease Dementia Health Care Heart Diseases Mental Disorders Mouth Diseases Myocardial Ischemia Neoplasms Nervous System Diseases Neurocognitive Disorders Neurologic Manifestations Nutrition Disorders Nutritional and Metabolic Diseases Obesity Ocular Diseases Overnutrition Overweight Pathological Conditions, Signs and Symptoms Periodontal Diseases Psychophysiologic Disorders Respiration Disorders Respiratory Disease Respiratory Tract Diseases Signs and Symptoms Stomatognathic Diseases Stroke Vascular Diseases

Age range

45 year–74 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Universitätsklinikum Hamburg-Eppendorf

Hamburg, 20246, Germany

Location status: Recruiting

Location contact

Susannw Bruder

CONTACT

[email protected]

00494056045

About this study

A random sample of 45.000 participants between 45 and 74 years of age from the general population of Hamburg, Germany, will take part in an extensive baseline assessment at a dedicated study center. Participants undergo 13 validated and 5 novel examinations primarily targeting cardiac, arterio-venous and cerebral function and structure including extensive imaging examinations. The protocol includes self-ratings of life style and environmental conditions, , dietary habits, physical activity, professional life, psychosocial context, , digital media use, medical and family history as well as health care utilization patterns. The assessment is completed by genomic and proteomic characterization. Beyond the identification of classical risk factors for major chronic diseases and survivorship, the core intention is to develop complex models predicting health outcomes based on a multitude of examination data, imaging data and behavioral assessments. Participants at risk for coronary artery disease, atrial fibrillation, heart failure, stroke and dementia will be invited for a visit to conduct additional MRI examination either of heart or brain. Endpoint assessment of the overall sample will be completed through repeated follow-up examinations and data from involved health and pension insurances.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Inhabitant of the city of Hamburg at the time of inclusion into the study (Inclusion is time of written consent)
Age 45 to 74 years
Personally signed informed consent

Exclusion criteria

Insufficient knowledge of the German language, in order to understand study documents and computer assisted interview without translation
Physical or psychological incapability to travel to the study center and to cooperate in the investigations

Treatment and study plan

Primary outcomes

self-reported Information on changes in health in the participants

Time frame: yearly up to 12 years

coronary artery disease atrial fibrillation heart failure dementia stroke cancer such as prostate cancer and skin cancer chronic kidney diseases migraine musculoskeletal diseases such as osteoporosis and bone metastasis ocular diseases such as glaucoma, macular degeneration, fundus hypertonicus, retinal vessel disease and neoplasm oral health including periodontal disease, oropharyngeal cancer and human papillomavirus (HPV)-infection psychiatric and psychosomatic disorders such as mental disorder or late - last depression pulmonary diseases such as obstructive lung disease sexual disorder skin diseases such as psoriasis, chronic wounds and inflammation vascular diseases such as aortic aneurysm, thrombosis and peripheral arterial disease

Study contacts

Contact information is provided by the study sponsor or research team.

Annika Jagodzinski, MD

CONTACT

[email protected]

0049741059328

Tanja Zeller, Professor

CONTACT

[email protected]

0049741056045

Sponsors and collaborators

Lead sponsor

Universitätsklinikum Hamburg-Eppendorf

Other

Collaborators

Martini-Klinik am UKE GmbH
University of Hamburg-Eppendorf

Registry information

Official study title

A Single Center, Prospective, Epidemiologic Cohort Study With Emphasis on Imaging to Improve the Identification of Individuals at Risk for Major Chronic Diseases and to Improve Early Diagnosis and Survival

Acronym: HCHS

Important dates

Study start: 2016
Primary completion: 2022
Study completion: 2028
First posted: May 2, 2019
Registry last updated: May 2, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Recruiting