Examining the Long-Term Risks of Oophorectomy

At the time of hysterectomy for benign disease, the overall health benefits of preserving ovarian function in a large population of women have not been established.

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Key information

Conditions

Coronary Heart Disease Adnexal Diseases Brain Diseases Breast Cancer Breast Diseases Breast Neoplasms Cancer Cardiovascular Diseases Central Nervous System Diseases Cerebrovascular Disorders Coronary Disease Death Endocrine Gland Neoplasms Endocrine System Diseases Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Femoral Fractures Fractures, Bone Genital Diseases Genital Diseases, Female Genital Neoplasms, Female Gonadal Disorders Heart Diseases Hip Fracture Hip Fractures Hip Injuries Leg Injuries Myocardial Ischemia Neoplasms Neoplasms by Site Nervous System Diseases Ovarian Cancer Ovarian Diseases Ovarian Neoplasms Pathologic Processes Pathological Conditions, Signs and Symptoms Skin Diseases Skin and Connective Tissue Diseases Stroke Urogenital Diseases Urogenital Neoplasms Vascular Diseases Wounds and Injuries

Age range

30 year–55 year

Sex eligibility

Female

Study type

Observational

Primary location

Parker, Rosenman, Rodi Gynecology Group

Santa Monica, California, 90401, United States

About this study

We are conducting a prospective, observational study of 32,175 women participants of the Nurse's Health Study who had a hysterectomy with or without removal of both ovaries. We are evaluating mortality and morbidity due to the following conditions: coronary heart disease, stroke, breast cancer, ovarian cancer, other cancer, hip fracture and death from all causes.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Women who had hysterectomies were classified into simple hysterectomy or hysterectomy with both ovaries removed.

Exclusion criteria

Evidence of cancer, coronary heart disease (MI or Angina Pectoris), stroke, or hip fracture before entering the study were excluded. Cancer as an indication for hysterectomy also excluded.
Women reporting unilateral oophorectomy, unknown oophorectomy status, unknown age of hysterectomy, or those who had oophorectomy before hysterectomy were excluded.

Treatment and study plan

Primary outcomes

mortality and morbidity due to the following conditions: coronary heart disease, stroke, breast cancer, ovarian cancer, other cancer, hip fracture and death from all causes.

Time frame: 28 years

Secondary outcomes

The effect of postmenopausal hormone use on mortality and morbidity due to the following conditions: coronary heart disease, stroke, breast cancer, ovarian cancer, other cancer, hip fracture and death from all causes.

Time frame: 28 years

Sponsors and collaborators

Lead sponsor

Parker, William H., M.D.

Other

Collaborators

Ethicon, Inc.

Registry information

Official study title

Ovarian Conservation: Long-Term Health Outcomes From the Nurse's Health Study.

Important dates

Study start: 1980
Primary completion: 2004
Study completion: 2004
First posted: Apr 9, 2008
Registry last updated: Apr 9, 2008

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

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