Gut Microbiota in Obesity and Diabetes

An altered gut microbiota composition has recently been linked to obesity and diabetes. The principal aim of this study was to investigate and compare the gut microbiota composition of obese, diabetic and control individuals. Then, associations between analyzed gut microbial concentrations and clinical-biochemical blood parameters were assessed.

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Key information

Conditions

Obesity Body Weight Diabetes Mellitus Diabetes Mellitus, Type 2 Endocrine System Diseases Glucose Metabolism Disorders Metabolic Diseases Nutrition Disorders Nutritional and Metabolic Diseases Overnutrition Overweight Pathological Conditions, Signs and Symptoms Signs and Symptoms Type 2 Diabetes Mellitus

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Department of Endocrinology and Metabolism, Gulhane School of Medicine

Ankara, 06180, Turkey (Türkiye)

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Subjects with obesity or newly diagnosed type 2 diabetes
18 years to 65 years of age

Exclusion criteria

Any chronic disease (other than obesity and diabetes)
Alcohol consumption/smoking
Pregnancy/breastfeeding
The use of antibiotics, pro-prebiotics within 3 months
<18 years or >65 years
History of intestinal surgery

Treatment and study plan

Comparison of the gut microbiota composition

Other

Primary outcomes

The comparison of the gut microbiota composition

Time frame: 9 months

The gut microbiota composition of obese, diabetic and control individuals was analyzed by quantitative real-time PCR (qRT-PCR)

Secondary outcomes

The relationship between metabolic parameters and the gut microbiota composition

Time frame: 9 months

A multivariate linear regression analysis was performed in order to test associations between the gut microbiota composition and metabolic variables of participants

Sponsors and collaborators

Lead sponsor

Gulhane School of Medicine

Other

Registry information

Official study title

Comparison of Gut Microbiota in Obese, Diabetic and Healthy Control Individuals

Important dates

Study start: 2013
Primary completion: 2013
Study completion: 2013
First posted: Jul 2, 2014
Registry last updated: Jul 2, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed