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Completed

NCT Number: NCT01366768

Gut Hormones After Oral Versus Intravenous Amino Acids

The study hypothesis is that gut hormones are released after oral but not intravenous amino acids which result in stimulation of insulin secretion.

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Key information

Conditions

Normal Non-fluency

Age range

20 year–30 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Department of Clinical Sciences Lund, Lund University

Lund, 221 84, Sweden

About this study

Amino acid mixture is given orally or intravenously to match total concentrations of amino acids in healthy subjects. Samples are taken regularly for 300 min after administrations. Plasma levels of the gut hormones glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1)and determined and related to plasma levels of insulin and glucagon.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy subjects

Exclusion criteria

  • Diabetes
  • Liver disease
  • Kidney disease
  • Thyroid disease

Treatment and study plan

Oral amino acid mixture

Other

Amino acid mixture 2,93 ml/kg

Other names: Amino acid mixture

Intravenous amino acid administration

Other

Amino acid mixture 2,93 ml/kg

Other names: Amino acid mixture

Primary outcomes

  1. Gut hormone secretion

    Time frame: 300 min

Secondary outcomes

  1. Insulin secretion

    Time frame: 300 min

Sponsors and collaborators

Lead sponsor

Lund University

Other

Registry information

Official study title

Release of Gut Hormones After Oral Versus Intravenous Amino Acids

Important dates

Study start
2011
Primary completion
2012
Study completion
2012
First posted
Jun 6, 2011
Registry last updated
Oct 10, 2012

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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