Guided Bone Regeneration Using Bovine-derived Xenograft in Combination With or Without Injectable Platelet-rich Fibrin

The study was conducted on patients who had partially edentulism with horizontal deficiency of the alveolar bone in the posterior regions of mandible.

All patients were informed about treatment protocol of the study and also, the risks and benefits associated with participation. Each patient provided written informed consent prior to enrollment.

Randomization was performed after the dental implant surgeries and the patients were randomly assigned to one of the study groups:

Test group included 22 patients treated with GBR using i-PRF-enriched bovine-derived xenograft + resorbable membrane Control group included 22 patients treated with GBR using bovine-derived xenograft + resorbable membrane All patients underwent two-stage surgical protocol that performed by the same experienced surgeon. Following implant placement, i-PRF-enriched bovine-derived xenograft for the test group and bovine-derived xenograft alone for the control group was carefully positioned with light compression around the implants. Finally, the resorbable membrane was placed to cover the augmented area.

As the second stage of surgery, healing caps were placed and the implant-supported fixed prosthesis were completed in approximately one to two months.

Inclusion criteria

• horizontal deficiency of the alveolar bone in the posterior regions of mandible
• absence of periodontal disease or previously treated
• with blood tests showing platelet counts at least 150.000 mm3
• ability to understand and accept the requirements of the study.

Exclusion criteria

• any disorders or infection at the implantation site or adjacent tissue
• tooth loss or extraction in the planned implant site within 6 months
• poor oral hygiene
• medical conditions that compromised tissue healing (uncontrolled diabetes, etc.)
• treatments with an interfering medications (bisphosphonates, steroids etc.)
• smoking habit
• pregnancy or nursing