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Completed

NCT Number: NCT00606996

Group Therapy for Women Prisoners With Comorbid Substance Use and Depression

The purpose of the study is to determine whether interpersonal psychotherapy is effective for treating co-occurring depression and substance use among women prisoners.

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Key information

Age range

18 year–65 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Adult Correctional Institution

Cranston, Rhode Island, 02920, United States

About this study

Incarcerated women are a vulnerable and rapidly expanding population with high lifetime rates of both substance use disorder (SUD; abuse or dependence on alcohol, illegal drugs, or prescription drugs; 70%) and depressive disorder (DD; major depressive disorder and dysthymic disorder; 20-27%). DDs tend to worsen the course of SUDs for incarcerated women by increasing their risk for suicide attempts, contributing to the persistence of substance abuse, and reducing the likelihood of a successful transition to an independent, sober life in the community. Recent evidence indicates that DDs are common in persons with SUDs, often do not remit with SUD treatment, and should be treated. Despite growing recognition that co-occurring disorders, such as DDs, among substance abusing incarcerated women present an important public health concern, integrated treatments for SUD-DD have not been well-developed for or systematically tested in this population. Group Interpersonal Psychotherapy (IPT-G) has been shown to be efficacious in treating DD in other populations and may be especially pertinent to the needs of incarcerated women with SUD-DD because interpersonal difficulties not only affect severity of depression, but are also strong predictors of drinking to cope, SUD relapse, and prison recidivism in women.

This study tests the hypotheses that as adjuncts to prison SUD treatment, IPT-G, relative to psychoeducation on co-occurring disorders, will produce at least moderate effect sizes for:

  • Reduction in the risk and severity of substance use relapse after release from prison
  • Recovery from depressive disorder and reduction in depressive symptoms
  • Improvement in social support and interpersonal functioning
  • Reduction in the severity of legal problems during the 3 month follow-up period

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Participants are recruited from prison substance use treatment programs.
  • Current primary (non-substance-induced, as defined by the SCID) depressive disorder (major depressive or dysthymic disorder) after at least 4 weeks of prison SUD treatment and abstinence.
  • A minimum Hamilton Depression score of 18 or higher, indicating moderate to severe depression.
  • Depressive disorder at any time while not incarcerated.
  • Substance use disorder one month prior to incarceration.
  • Between 10 and 18 weeks away from release from prison.

Exclusion criteria

  • Lifetime criteria for bipolar disorder
  • Lifetime criteria for a psychotic disorder
  • Actively suicidal

Treatment and study plan

Group interpersonal psychotherapy (IPT-G)

Behavioral

Psychoeducation on co-occurring disorders (PSYCHOED)

Behavioral

Primary outcomes

  1. Substance-free days after release from prison, measured by the Timeline Followback method

    Time frame: 3 months post-release

  2. Severity of substance use after release from prison, measured by the Addiction Severity Index

    Time frame: 3 months post-release

  3. Verification of substance-free status using breath alcohol tests and urine drug screens

    Time frame: 3 months post-release

  4. Depression symptom severity measured by the Modified Hamilton Rating Scale for Depression

    Time frame: Pre-release

  5. Depression symptom severity measured by the Beck Depression Inventory

    Time frame: Pre-release

Secondary outcomes

  1. Severity of legal problems after release, measured by the Legal Composite of the Addiction Severity Index

    Time frame: 3 months post-release

  2. Interpersonal problems, measured by the Inventory of Interpersonal Problems

    Time frame: 3 months post-release

  3. Peer support and social support, measured by the Criminal Justice client Evaluation of Self and Treatment

    Time frame: 3 months post-release

  4. Perceived social support measured by the Multidimensional Scale of Perceived Social Support

    Time frame: 3 months post-release

  5. Social support for recovery, measured by the Important People and Activities scale

    Time frame: 3 months post-release

  6. Social functioning, measured by the Social Adjustment Scale

    Time frame: 3 months post-release

Sponsors and collaborators

Lead sponsor

Brown University

Other

Registry information

Official study title

Group IPT for Women Prisoners With Comorbid Substance Use and Depression

Important dates

Study start
2006
Primary completion
2009
Study completion
2009
First posted
Feb 5, 2008
Registry last updated
Mar 20, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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