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Completed

NCT Number: NCT04953338

Mental Health Associations With Vitiligo

This cohort study is a large population-based study in the UK to determine the risks of comorbid mental health conditions (including depression, anxiety and other potential psychological complications of vitiligo) in adults with vitiligo compared to controls and to evaluate whether the relative risks may vary by different ethnicity.

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Key information

Conditions

Vitiligo Adjustment Disorders Anxiety Disorders Behavior Behavioral Symptoms Chemically-Induced Disorders Depressive Disorder Depressive Episode Drug Misuse Drug Overdose Hypopigmentation Mental Disorders Mood Disorders Overdose Parasuicide Phobia, Social Phobic Disorders Pigmentation Disorders Prescription Drug Misuse Recurrent Depressive Disorder Self-Harm, Deliberate Self-Injurious Behavior Skin Diseases Skin and Connective Tissue Diseases Social Phobia Substance Abuse Substance-Related Disorders Suicide Suicide, Attempted Trauma and Stressor Related Disorders

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Momentum Data Ltd

London, WC1X 8QT, United Kingdom

About this study

This study has two primary outcomes 1) Prevalence and incidence of mental health condtions in people diagnosed with vitiligo compared to matched controls and 2) Primary care and secondary healthcare utilisation in patients diagnosed with vitiligo and having a prevalent depressive conditon compared to matched controls. In addition, the study examines risk of time off work and unemployment in people diagnosed with vitiligo compared to matched controls.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • All eligible adults ≥18 (as at date of vitiligo diagnosis for cases or start of follow-up for controls) registered with GP practices contributing data to OPCRD between January 1, 2004 and December 31, 2020, were eligible for inclusion in the study.

Exclusion criteria

  • People with less than 1 year of follow up available

Treatment and study plan

Exposure of mental health condtion of interest

Other

Common mental health conditions consist of depressive episodes, recurrent depressive disorder and anxiety disorder.

Primary outcomes

  1. Number of Participants With Depressive Episodes

    Time frame: At the time of diagnosis in all people diagnosed with vitiligo 2004-2020 inclusive. For matched controls, the date of diagnosis of their matched case.

    Prevalence of common mental health conditions (depressive episodes) in adult people diagnosed with vitiligo and matched controls without vitiligo.

  2. Risk of Depressive Episodes Within Adult Patients With Vitiligo

    Time frame: Within two years of vitiligo diagnosis. For matched controls, within two years of the date of diagnosis of their matched case.

    Adjusted hazard ratio calculated using Cox proportional hazards models

  3. Number of Participants With Anxiety Disorder

    Time frame: At the time of diagnosis in all people diagnosed with vitiligo 2004-2020 inclusive. For matched controls, the date of diagnosis of their matched case.

    Prevalence of common mental health conditions (Anxiety Disorder) in adult people diagnosed with vitiligo and matched controls without vitiligo.

  4. Number of Participants With Recurrent Depressive Disorder

    Time frame: At the time of diagnosis in all people diagnosed with vitiligo 2004-2020 inclusive. For matched controls, the date of diagnosis of their matched case.

    Prevalence of common mental health conditions (Recurrent Depressive Disorder) in adult people diagnosed with vitiligo and matched controls without vitiligo.

  5. Risk of Anxiety Disorder Within Adult Patients With Vitiligo

    Time frame: Within two years of vitiligo diagnosis. For matched controls, within two years of the date of diagnosis of their matched case.

    Adjusted hazard ratio calclulated using Cox Proportional hazard models

  6. Risk of Recurrent Depressive Disorder Within Adult Patients With Vitilgo

    Time frame: Within two years of vitiligo diagnosis. For matched controls, within two years of the date of diagnosis of their matched case.

    Adjusted hazard ratio calculated using Cox proportional hazards models. Adjusted for age, gender, ethnicity, social deprivation quintile, body mass index, smoking status, alcohol use and comorbidities (hypertension, hyperlipidaemia, type 2 diabetes, atrial fibrillation, angina, myocardial infarction, heart failure, stroke, chronic kidney disease stages 3-5, chronic obstructive pulmonary disease, asthma, chronic liver disease and dementia).

Sponsors and collaborators

Lead sponsor

Momentum Data

Industry

Collaborators

  • Pfizer

Registry information

Official study title

The Mental Health Associations With Vitiligo: a Population-based Cohort Study in the UK

Important dates

Study start
2021
Primary completion
2022
Study completion
2022
First posted
Jul 7, 2021
Registry last updated
Dec 2, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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