Rambam MC
Haifa, Israel
NCT Number: NCT02077660
The purpose of this study is to evaluate the beneficial effects of a long term (12 weeks) green tea drinking on plasma, erythrocytes and saliva oxidative stress biomarkers and antioxidant capacity, as well as on cardiometabolic risk factors: anthropometric, inflammation and metabolic parameters in a healthy aging men and women.
Looking for future studies?
Notify Me60 year–76 year
All sexes
Interventional
Not applicable
Haifa, Israel
A prospective, crossover trial in which every individual served its own control. All subjects undergo a four weeks washout period, during which they briefed to avoid tea drinking and antioxidant supplements until the end of the study. At the end of the washout period, blood and saliva samples is collected after 12 hours of night fast. Subsequently, all subjects receive the maltodextrin containing placebo "tea bags". The subjects instructed to brew the placebo sachets for five minute in 240 mL boiling water without stirring and to drink 4 cups per day for 12 weeks period (placebo period). After the placebo period, fasting samples collected once more and the subjects receive the green tea bags. Preparation and drinking instructions are the same as the placebo drink. At the end of the 12 weeks, green tea drinking, fasting blood and saliva samples drawn for the third time. During the study, every 4 weeks the subjects get additional placebo or green tea bags. Assessment of nutritional consumption of macronutrients and antioxidants using a food diary, physical activity lifestyle as well as weight, body fat and circumference measurements is made at the beginning, middle and end of the study.
Healthy volunteers accepted: Yes
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
Exclusion criteria
Four green tea bags per day for 12 weeks
4 daily placebo tea bags for 12 weeks
Time frame: 24 weeks
Protein carbonyls, nmol/mg
Time frame: 24 weeks
Thiobarbituric acid reactive substance , nmol/mL
Time frame: 24 weeks
Lipid peroxides, nmol/mL
Time frame: 24 weeks
Catalase activity, milliunits/mg
Time frame: 24 weeks
hemolysis test, percentage
Time frame: 24 weeks
Oral peroxidase activity, milliunits/mg
Time frame: 24 weeks
Total antioxidant capacity, millimolar/mg
Time frame: 24 weeks
Body weight, kg
Time frame: 24 weeks
Body fat, %
Time frame: 24 weeks
Waist and hip circumference, cm
Time frame: 24 weeks
Serum C-reactive protein mg/dL
Time frame: 24 weeks
Saliva matrix metalloproteinase 8, µg/L
Time frame: 24 weeks
Saliva interleukin 8, ng/L
Rambam Health Care Campus
Other
The Effect of Green Tea on Anthropometric, Oxidation and Inflammation Parameters in Physically Active Elderly Compared to Sedentary Elderly
Acronym: GT
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.
Published trials that share one or more normalized conditions with this study.
NCT05610059
Aging, Behavior
Tucson, Arizona, United States
View Trial DetailsNCT05017129
Aging
Golden, Colorado, United States
View Trial DetailsNCT03814304
Accidental Falls, Aging
Roslindale, Massachusetts, United States
View Trial DetailsNCT05866393
Aging, Behavior
Cleveland, Ohio, United States
View Trial Details