Granuloma Annulare Treated With Rifampin, Ofloxacin, and Minocycline Combination Therapy

Granuloma annulare is a benign, usually self-limiting, cutaneous dermatosis, which typically presents as asymptomatic, flesh-colored or red papules, frequently arranged in an annular pattern on the distal extremities. Although localized granuloma annulare is most commonly observed, a generalized or disseminated form can occur. The etiology of granuloma annulare is unknown, however, multiple inciting factors have been proposed. The purpose of the investigators is to review the outcomes of treatment of granuloma annulare (GA) resistant to standard regimens that resolved after a 3-months treatment course of monthly rifampin, ofloxacin, and minocycline (ROM) therapy, successfully used to treat paucibacillary leprosy, a disease with clinical and histopathologic similarity to GA.

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Key information

Conditions

Granuloma Annulare Collagen Diseases Connective Tissue Diseases Granuloma Necrobiotic Disorders Pathologic Processes Pathological Conditions, Signs and Symptoms Skin Diseases Skin and Connective Tissue Diseases

Sex eligibility

All sexes

Study type

Observational

Primary location

Henry Ford Medical Center

Detroit, Michigan, 48202, United States

About this study

We will document the regimen treatment each patient has had and then review the following from the patient's chart to target our specific aims as outlined above.

What previous treatment options have been or/are currently being used?
How long did the patient take the treatment for?
Was the patient able to discontinue or become less dependent on prior treatment?
Was the disease process slowed by the treatment?;
Were there any side effects that the patient experienced with treatment?

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients with granuloma annulare who are resistent to the standard treatment.

Exclusion criteria

Response to the standard treatment of granuloma annulare.

Sponsors and collaborators

Lead sponsor

Henry Ford Health System

Other

Registry information

Important dates

Study start: 2008
Primary completion: 2008
Study completion: 2008
First posted: Jul 23, 2008
Registry last updated: Apr 30, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed