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NCT Number: NCT05472636

Evaluation of 41 Cases of Pediatric Granuloma Annulare

INTRODUCTION: Granuloma annulare is a non-infectious, granulomatous disease that can affect children and adults. Although there are many studies examining adult patients, there are limited studies examining pediatric granuloma annulare cases. It is aimed to examine the demographic, clinical, and pathological features of pediatric granuloma annulare cases in this study.

MATERIALS and METHODS: This study was performed retrospectively in a single-center, tertiary dermatology hospital. Forty-one patients, under the age of 18 who were admitted to the dermatology outpatient clinic between 2008-2021 and diagnosed with granuloma annulare were scanned from the hospital database and patient photograph archive. Demographic characteristics, and clinical and histopathological features were evaluated.

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Key information

Conditions

Granuloma Annulare Collagen Diseases Connective Tissue Diseases Granuloma Necrobiotic Disorders Pathologic Processes Pathological Conditions, Signs and Symptoms Skin Diseases Skin and Connective Tissue Diseases

Age range

Up to 18 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Istanbul Training and Research Hospital

Istanbul, 34098, Turkey (Türkiye)

About this study

Granuloma annulare; is a non-infectious, granulomatous skin reaction with potential triggers that can affect the adult and pediatric age group. Diabetes mellitus, hyperlipidemia, and malignancy have been described in association with adult granuloma annulare cases. While there are studies on the clinical, pathological features and associated diseases in patients with adult granuloma annulare, a limited number of studies have been conducted on pediatric granuloma annulare patients. Therefore, clinical and histopathological evaluation of pediatric granuloma annulare cases was planned in our study.

This study was performed retrospectively in a single-center tertiary dermatology hospital. Patients under the age of 18 who were admitted to the dermatology outpatient clinic between 2008-2021 and diagnosed with granuloma annulare were scanned from the hospital database and patient photograph archive. Cases with uncertain diagnosis were not included in the study. Cases with dermatological findings recorded in detail and/or diagnosed histopathologically were included in the study. Demographic features, lesion localization, lesion characteristics (size, elementary lesion, color), involvement (localized/generalized), histopathological features, concomitant diseases, differential diagnoses in cases with histopathology, regression time and recommended treatments were recorded.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Being under 18 years old
  • Having granuloma annulare
  • Applying to the Istanbul Training and Research Hospital, Dermatology Outpatient Clinic between 2008-2021
  • Consenting to participate in the study

Exclusion criteria

-Being over 18 years old

Treatment and study plan

Primary outcomes

  1. Evaluation of the genders of the pediatric patients with granuloma annulare

    Time frame: day 0

    male, female

  2. Evaluation of the ages of the pediatric patients with granuloma annulare

    Time frame: day 0

    age (year)

  3. Evaluation of the concomitant diseases of the pediatric patients with granuloma annulare

    Time frame: day 0

    the concomitant diseases of the participants

  4. Evaluation of the lesion localization of the pediatric patients with granuloma annulare

    Time frame: day 0

    head and neck, upper extremity, lower extremity, trunk

  5. Evaluation of the lesion duration of the pediatric patients with granuloma annulare

    Time frame: day 0

    the time interval in between appearance of the lesion and diagnosis (month)

  6. Evaluation of the lesion type of the pediatric patients with granuloma annulare

    Time frame: day 0

    papule, pustule, plaque, nodule

  7. Evaluation of the mean size of the lesion

    Time frame: day 0

    diameter (cm)

  8. Evaluation of the clinical involvement

    Time frame: day 0

    localized, generalized

  9. Histopathological evaluation of the infiltration type of the pediatric patients with granuloma annulare

    Time frame: day 0

    neutrophilic, lymphocytic, lymphohistiocytic, eosinophil, mixed infiltrations

  10. Histopathological evaluation of the infiltration pattern of the pediatric patients with granuloma annulare

    Time frame: day 0

    Interstitial, palisadic

  11. Evaluation of epidermal findings

    Time frame: day 0

    regular/irregular, hyperkeratosis, acanthosis

  12. Evaluation of depth of infiltrate

    Time frame: day 0

    superficial, medium, deep

Sponsors and collaborators

Lead sponsor

Istanbul Training and Research Hospital

Other Gov

Registry information

Official study title

Clinical and Histopathological Evaluation of 41 Cases of Pediatric Granuloma Annulare

Important dates

Study start
2022
Primary completion
2022
Study completion
2022
First posted
Jul 25, 2022
Registry last updated
Jul 25, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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