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NCT Number: NCT07552571

Goal Commitment and Proactive Health Behavior in Chronic Disease Patients

Chronic diseases such as hypertension, diabetes, and dyslipidemia are major contributors to mortality and healthcare burden worldwide. Despite high awareness of health risks, many patients fail to adopt proactive health behaviors due to behavioral inertia and a gap between knowledge and action.

This study aims to investigate the evolution and driving mechanisms of proactive health behavior in patients with chronic diseases based on goal commitment theory. By integrating prospect theory and evolutionary game theory, this study will explore how behavioral strategies evolve under different levels of goal commitment.

In addition, a behavioral intervention based on the Stimulus-Organism-Response (SOR) model will be developed to enhance patient activation and promote adherence to proactive health behaviors. A parallel controlled intervention study will be conducted to evaluate the effectiveness of the goal commitment-based intervention.

The findings of this study are expected to provide theoretical and practical evidence to improve chronic disease management and promote proactive health behaviors.

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Key information

Age range

45 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

School of Medicine and Health Management Tongji Medical College,Huazhong University of Science and Technology

Wuhan, Hubei, 430030, China

Location status: Recruiting

Location contact

Juyang Xiong, Ph.D.

CONTACT

[email protected]

+86-139 9562 9873

About this study

Chronic diseases, including hypertension, diabetes, and dyslipidemia, account for a substantial proportion of morbidity, mortality, and healthcare expenditure. Although a large proportion of patients are aware of their health risks, more than half fail to adopt proactive health behaviors. This gap between awareness and action is often attributed to behavioral inertia and insufficient motivation.

This study aims to explore the evolution and driving mechanisms of proactive health behavior among patients with chronic diseases based on goal commitment theory. The theoretical framework integrates prospect theory and evolutionary game theory to model behavioral decision-making under uncertainty and dynamic interactions.

First, a theoretical model will be constructed to simulate the evolution of proactive health behaviors under different levels of goal commitment, using evolutionary game analysis. Second, a conceptual framework based on the Stimulus-Organism-Response (SOR) model will be developed to examine how goal commitment influences patient activation and social norms, thereby affecting proactive health behavior.

Empirical data will be collected through multi-site surveys among patients with chronic diseases. Subsequently, a parallel controlled intervention study will be conducted to evaluate the effectiveness of a goal commitment-based intervention in improving proactive health behaviors.

Inclusion criteria

include adult residents diagnosed with at least one chronic condition (hypertension, diabetes, or dyslipidemia), with adequate cognitive ability and willingness to participate. Exclusion criteria include inability to participate in group activities, current hospitalization, or severe psychiatric or cognitive disorders.

The study is expected to provide insights into the mechanisms underlying proactive health behavior and offer evidence-based strategies for improving chronic disease management.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Residents living in the study area for at least 1.5 years
  • Diagnosed with at least one chronic disease, including hypertension, diabetes mellitus, or dyslipidemia
  • Conscious and able to communicate effectively
  • Educational level of primary school or above
  • Able to use a smartphone and common mobile applications (e.g., WeChat)
  • Willing to participate and provide written informed consent

Exclusion criteria

  • Non-residents of the study area
  • Unable to participate in group-based intervention activities
  • Currently hospitalized
  • Diagnosed with severe cognitive impairment, dementia, or psychiatric disorders
  • Participants with severe comorbidities that may interfere with study participation

Treatment and study plan

Goal Commitment-Based Behavioral Intervention

Behavioral

This intervention is a structured behavioral program based on goal commitment theory, designed to promote proactive health behaviors in patients with chronic diseases. The intervention includes goal setting, personalized action planning, behavioral activation, and continuous follow-up support. Participants will receive guidance to enhance motivation, strengthen commitment to health goals, and improve adherence to chronic disease management through regular monitoring and feedback.

Usual Care

Other

Participants in the control group will receive routine chronic disease management or standard health education without additional structured behavioral intervention.

Primary outcomes

  1. Change in Proactive Health Behavior Score

    Time frame: Baseline to 6 months after intervention

    The primary outcome is the difference in the mean change of proactive health behavior scores between the intervention group and the control group at 6 months after the intervention. Proactive health behaviors will be assessed using a validated Proactive Health Behavior Scale, including overall score and component scores.

Secondary outcomes

  1. Change in Metabolic Syndrome (MetS) Score

    Time frame: Baseline to 6 months after intervention

    The primary outcome includes the difference in the mean change of metabolic syndrome (MetS) scores between the intervention group and the control group at 6 months after the intervention.

  2. Change in Proactive Health Behavior Score at 3 Months

    Time frame: Baseline to 3 months after intervention

    The difference in the mean change of proactive health behavior scores and its component domains between the intervention group and the control group at 3 months after the intervention.

  3. Change in Fasting Blood Glucose (FBG) at 3 Months

    Time frame: Baseline to 3 months after intervention

    The difference in the mean change of fasting blood glucose levels between the intervention group and the control group at 3 months after the intervention.

  4. Change in Fasting Blood Glucose (FBG)

    Time frame: Baseline, 3 months, and 6 months after intervention

    Changes in fasting blood glucose levels measured by blood tests.

  5. Change in Triglycerides (TG)

    Time frame: Baseline, 3 months after intervention, and 6 months after intervention

    Changes in triglyceride levels measured by blood tests.

  6. Change in High-Density Lipoprotein Cholesterol (HDL-C)

    Time frame: Baseline, 3 months after intervention, and 6 months after intervention

    Changes in HDL cholesterol levels measured by blood tests.

  7. Change in Blood Pressure

    Time frame: Baseline, 3 months after intervention, and 6 months after intervention

    Changes in systolic and diastolic blood pressure.

  8. Change in Body Mass Index (BMI) at 3 Months

    Time frame: Baseline to 3 months after intervention

    The difference in the mean change of body mass index between the intervention group and the control group at 3 months after the intervention.

  9. Change in Triglycerides (TG) at 3 Months

    Time frame: Baseline to 3 months after intervention

    The difference in the mean change of triglyceride levels between the intervention group and the control group at 3 months after the intervention.

  10. Change in High-Density Lipoprotein Cholesterol (HDL-C) at 3 Months

    Time frame: Baseline to 3 months after intervention

    The difference in the mean change of HDL cholesterol levels between the intervention group and the control group at 3 months after the intervention.

  11. Change in Systolic Blood Pressure (SBP) at 3 Months

    Time frame: Baseline to 3 months after intervention

    The difference in the mean change of systolic blood pressure between the intervention group and the control group at 3 months after the intervention.

  12. Change in Diastolic Blood Pressure (DBP) at 3 Months

    Time frame: Baseline to 3 months after intervention

    The difference in the mean change of diastolic blood pressure between the intervention group and the control group at 3 months after the intervention.

Study contacts

Contact information is provided by the study sponsor or research team.

Juyang Xiong, PhD

CONTACT

[email protected]

+86-13995629873

Sponsors and collaborators

Lead sponsor

Xiong Juyang

Other

Registry information

Official study title

Evolution and Driving Mechanism of Proactive Health Behavior in Chronic Disease Patients Based on Goal Commitment

Important dates

Study start
2025
Primary completion
2028
Study completion
2028
First posted
Apr 27, 2026
Registry last updated
May 6, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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