Skip to main content
OpenTrials
Completed

NCT Number: NCT06694909

Glutamate Modulation of tDCS Over Premotor Cortex Combined With Peripheral Nerve Stimulation Promoted Observation-execution-related Cortical Excitability and Motor Learning

This study aimed to investigate whether concurrent tDCS over the PMC and PNS during action observation enhance observation-execution-related motor cortex excitability and improve motor performance, and to explore the underlying mechanism

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Brain Stimulation Cortical Excitability Motor Observation Peripheral Nerve Stimulation

Age range

18 year–33 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Beijing Sport University

Beijing, Haidian, 100084, China

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • normal or corrected-to-normal vision
  • right-handed

Exclusion criteria

  • pregnancy
  • a history of epilepsy
  • implanted medical devices
  • history or presence of neurological, psychiatric or musculoskeletal disorders, other medical conditions, and left-handedness

Treatment and study plan

tDCS + PNS with action observation

Device

tDCS: transcranial direct current stimulation; PNS: peripheral nerve stimulation

sham tDCS + sham PNS with action observation

Device

tDCS: transcranial direct current stimulation; PNS: peripheral nerve stimulation

tDCS + PNS without action observation

Device

tDCS: transcranial direct current stimulation; PNS: peripheral nerve stimulation

sham tDCS + PNS with action observation

Device

tDCS: transcranial direct current stimulation; PNS: peripheral nerve stimulation

tDCS + sham PNS with action observation

Device

tDCS: transcranial direct current stimulation; PNS: peripheral nerve stimulation

Primary outcomes

  1. Motor-evoked potentials

    Time frame: Before interventions, and immediately after interventions

  2. intracortical facilitation assessed by transcranial magnetic stimulation

    Time frame: Before interventions, and immediately after interventions

  3. short-interval intracortical inhibition assessed by transcranial magnetic stimulation

    Time frame: Before interventions, and immediately after interventions

  4. Reaction times of action execution blocks

    Time frame: immediately after interventions

Sponsors and collaborators

Lead sponsor

Beijing Sport University

Other

Registry information

Important dates

Study start
2017
Primary completion
2018
Study completion
2018
First posted
Nov 19, 2024
Registry last updated
Nov 19, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.