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NCT Number: NCT07360249

Glucose-fructose Ratio Pilot

The aim of this pilot study is to estimate the effect size of changing the glucose-fructose ratio from 1:0.5 to 1:1 on exogenous carbohydrate oxidation rates during exercise, which can be used to power a future definitive study.

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Key information

Conditions

Exercise Metabolism

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age: 18 years and above;
  • Performing endurance training for at least 5 hours per week
  • Capable of three hours of continuous exercise

Exclusion criteria

  • Glucose or lipid lowering, or weight loss medication
  • Diagnosis of cardiovascular disease, renal failure, liver disease or type 2 diabetes
  • Contraindications to exercise
  • Pregnant or lactating

Treatment and study plan

Glucose and fructose (one-to-one)

Other

Glucose and fructose ingested in solution in a one-to-one ratio (135 grams per hour for 3 hours during exercise)

Glucose and fructose (two-to-one)

Other

Glucose and fructose ingested in solution in a two-to-one ratio (135 grams per hour for 3 hours during exercise)

Primary outcomes

  1. Exogenous carbohydrate oxidation rate (g/h)

    Time frame: 180 minutes

    Total exogenous carbohydrate oxidation rate (g/h) over 180 minutes

Secondary outcomes

  1. Peak exogenous carbohydrate oxidation rate (g/h)

    Time frame: 180 minutes

    Highest recorded exogenous carbohydrate oxidation rate (g/h)

  2. Whole-body carbohydrate oxidation rate (g/h)

    Time frame: 180 minutes

    Total whole-body carbohydrate oxidation rate (g/h)

  3. Endogenous carbohydrate oxidation rate (g/h)

    Time frame: 180 minutes

    Total endogenous carbohydrate oxidation rate (g/h)

  4. Whole-body fat oxidation rate (g/h)

    Time frame: 180 minutes

    Total whole-body fat oxidation rate (g/h)

  5. Blood lactate concentrations (mmol/L)

    Time frame: 180 mninutes

    Mean blood lactate concentrations over 180 minutes

  6. Blood glucose concentrations (mmol/L)

    Time frame: 180 minutes

    Mean blood glucose concentrations (mmol/L) over 180 minutes

  7. Ratings of gut comfort (arbitrary units)

    Time frame: 180 minutes

    Mean ratings of gut comfort (arbitrary units) over 180 minutes

  8. Ratings of perceived exertion (arbitrary units)

    Time frame: 180 minutes

    Mean ratings of perceived exertion (arbitrary units) over 180 minutes

Other outcomes

  1. Exogenous carbohydrate oxidation over 2 hours (g/h)

    Time frame: 120 minutes

    Total exogenous carbohydrate oxidation over 2 hours (g/h)

Study contacts

Contact information is provided by the study sponsor or research team.

Javier Gonzalez

CONTACT

[email protected]

+441225385518

Sponsors and collaborators

Lead sponsor

University of Bath

Other

Registry information

Official study title

PILOT TEST OF GLUCOSE-FRUCTOSE RATIOS ON EXOGENOUS CARBOHYDRATE OXIDATION RATES DURING EXERCISE

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Jan 22, 2026
Registry last updated
Jan 22, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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