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NCT Number: NCT07447011

Glaucoma Respsosne to Lifestyle Corrections in Sleep Apnea

glaucoma is prevalent among obstructive sleep apnea (OSA). contnous passive airway pressure is main treatment of OSA. lifestyle corrections also recommended

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Key information

Conditions

Primary Open Angle Glaucoma Apnea Body Weight Dyssomnias Eye Diseases Glaucoma Glaucoma, Open-Angle Nervous System Diseases Nutrition Disorders Nutritional and Metabolic Diseases Obesity Obstructive Sleep Apnea Ocular Hypertension Overnutrition Overweight Pathological Conditions, Signs and Symptoms Respiration Disorders Respiratory Tract Diseases Signs and Symptoms Sleep Apnea Syndromes Sleep Apnea, Obstructive Sleep Disorders, Intrinsic Sleep Wake Disorders

Age range

30 year–50 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

About this study

forty glaucoma patients (high tension priamry open angle form) with OSA, intraocular pressure more than 21 mmHg, and obesity will be involved and divided to group I or group II (number of patients will be twenty in every group) for three month. both groups will apply CPAP during night sleeping daily for three month. group I will apply lifestyle corrections (low calories diet intake and 3-session per-week 40-minute treadmill walking for three month.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Obstructive sleep apnea patients
  • obese patients
  • glaucoma (open angle form with ocular hyoertension)

Exclusion criteria

cardiac patients renal patients hepatic patients

Treatment and study plan

lifetyle corrections and CPAP

Behavioral

twenty glaucoma patients (high tension priamry open angle form) with OSA, intraocular pressure more than 21 mmHg, and obesity will be involved in group I will apply CPAP during night sleeping daily for three month. group I will apply lifestyle corrections (low calories diet intake and 3-session per-week 40-minute treadmill walking for three month.

CPAP

Other

twenty glaucoma patients (high tension priamry open angle form) with OSA, intraocular pressure more than 21 mmHg, and obesity will be involved in group II will apply CPAP during night sleeping daily for three month.

Primary outcomes

  1. Intraocular pressure

    Time frame: it will be measured after 12 weeks

    it will be measured by tonometery

Secondary outcomes

  1. apnea hypopnea index

    Time frame: It will be measured after 12 weeks

    it is an indicator on numbe rof apnea during sleep

  2. Epowrth sleepiness scale

    Time frame: It will be measured after 12 weeks

    a questioanire assess rate of sleepiness

  3. body mass index

    Time frame: It will be measured after 12 weeks

    it assesed on empty bladder and bowel

  4. waist circumference

    Time frame: it will be measured after 12 weeks

    it will be assesed at umbilical level

  5. neck circumferfence

    Time frame: It will be measured after 12 weeks

    it is a measures of local fat around neck

  6. glaucoma related quality of life questioanire

    Time frame: It will be measured after 12 weeks

    it is 15-item questioanire assessing life quality in qlaucoma

Study contacts

Contact information is provided by the study sponsor or research team.

Ali MA Ismail, lecturer

CONTACT

[email protected]

01005154209

ali mohamed, lecturer

CONTACT

[email protected]

0201031321109

Sponsors and collaborators

Lead sponsor

Cairo University

Other

Registry information

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Mar 3, 2026
Registry last updated
Mar 3, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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