Skip to main content
OpenTrials
Completed

NCT Number: NCT01739283

GIP and GLP-1 in Type 1 Diabetes

Investigation of Glucose-dependent Insulinotropic Polypeptide (GIP) effects at hyper and hypoglycemia in type 1 diabetes.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Hypoglycemia Glucose Metabolism Disorders Metabolic Diseases Nutritional and Metabolic Diseases

Age range

18 year–50 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Gentofte Hospital

Hellerup, 2900, Denmark

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Diagnosed with type 1 diabetes (WHO criteria)

Exclusion criteria

  • HbA1c > 9 %
  • Liver disease (ALAT/ASAT > 2 x upper normal limit)
  • Diabetic nephropathy (s-creatinine > 130 µM or albuminuria)
  • Proliferative diabetic retinopathy (anamnestic)
  • Severe arteriosclerosis or heart failure (NYHA group III or IV)
  • Anemia
  • treatment with medication not applicable to pause for 12 hours
  • C-peptide increase after 50 g iv arginine

Treatment and study plan

GIP

Other

GLP-1

Other

Saline

Other

Primary outcomes

  1. plasma glucagon area under curve values

    Time frame: approx. 15 minutes intervals, time 0 to 120 min

Secondary outcomes

  1. plasma gut hormones and nutrients (absolute, incremental and area under curve values)

    Time frame: approx. 15 minutes intervals, time 0 to 120 min

Other outcomes

  1. Glucose and glycerol tracer kinetics

    Time frame: approx. 15 minutes intervals, time 0 to 120 min

  2. glucose (g/kg body weight) needed to be infuse to keep clamp

    Time frame: approx. 15 minutes intervals, time 0 to 120 min

Sponsors and collaborators

Lead sponsor

Mikkel Christensen

Other

Collaborators

  • University of Copenhagen

Registry information

Important dates

Study start
2012
Primary completion
2013
Study completion
2013
First posted
Dec 3, 2012
Registry last updated
Jul 13, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.