Genicular Nerve Phenol Neurolysis Versus Radiofrequency Ablation for Pain Relief in Grade 4 Knee Osteoarthritis

The goal of this clinical trial is to compare the efficiency and efficacy of genicular nerves blockade by chemical phenol neurolysis versus radiofrequency ablation in managing pain in patients suffering from grade IV KOA in term of NRS pain score.

The participants will be evaluated by numeric rating scale and oxford knee score for assessment of pain relief up to 16 weeks.

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Key information

Conditions

Joint Pain Arthralgia Arthritis Joint Diseases Musculoskeletal Diseases Neurologic Manifestations Osteoarthritis Osteoarthritis, Knee Pain Pathological Conditions, Signs and Symptoms Rheumatic Diseases Signs and Symptoms

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Grade 4 knee osteoarthritis according to Kellgren-Lawrence radiological classification.
Failure to manage pain with conservative methods.

Exclusion criteria

Prior knee replacement
Patients with cardiac pacemakers or implantable cardiac defibrillators.
Septic knee or systemic sepsis.
Allergy to any of the drugs used in the study.
Coagulopathy or patients on anticoagulants.
Patients with psychiatric illness.

Treatment and study plan

genicular nerve neurolysis

Procedure

The superior medial genicular nerve (SMGN), superior lateral genicular nerve (SLGN), and inferior medial genicular nerve (IMGN) will be blocked either by phenol neurolysis or radiofrequency ablation

Primary outcomes

Numeric rating scale

Time frame: baseline, 2, 4, 8,12 and 16 weeks after the procedure

By an independent physician pain will be recorded using numeric rating scale which is a screening tool used to assess pain severity using a 0 - 10 scale with zero meaning no pain and 10 meaning the worst pain ever.

Secondary outcomes

oxford knee score

Time frame: baseline, 4, 8, 12, 16 weeks after the procedure

This score is used to assess both function and pain of the knee on a scale ranging from 0 (worst pain and function) and 48 (best function and no pain) this score will be recorded by an independent physician

Study contacts

Contact information is provided by the study sponsor or research team.

ahmed boeith, MD

CONTACT

[email protected]

02001003074795

Sponsors and collaborators

Lead sponsor

Ain Shams University

Other

Registry information

Important dates

Study start: 2025
Primary completion: 2025
Study completion: 2025
First posted: Mar 7, 2025
Registry last updated: Mar 7, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed