Genetics of Uveitis

In order to improve the investigators knowledge about uveitis and the underlying mechanism of disease, the investigators propose collecting blood from patients with uveitis, isolating DNA and sequencing the DNA to identify genetic mutations or associations in these patients.

Recruiting

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Key information

Conditions

Uveitis Communicable Diseases Disease Attributes Eye Diseases Infections Infectious Uveitis Pathologic Processes Pathological Conditions, Signs and Symptoms Uveal Diseases

Age range

6 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Cleveland Clinic Foundation

Cleveland, Ohio, 44195, United States

Location status: Recruiting

Location contact

Kimberly M Baynes, COA

CONTACT

[email protected]

216-444-2566

Sunil K. Srivastava, M.D.

PRINCIPAL_INVESTIGATOR

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Any patient above with the diagnosis of uveitis.
Any patient with a diagnosis of infectious uveitis such as toxoplasmosis retinochoroiditis, herpes associated retinitis.

Exclusion criteria

Patients who are unable to give consent
Patients in whom an adequated blood sample can not be obtained.

Treatment and study plan

Primary outcomes

Non infectious uveitis

Time frame: 5 years

Distinct uveitis conditions will have a polymorphism association or specific mutation.

Secondary outcomes

Infectious uveitis

Time frame: 5 years

Infectious uveitis (such as herpes associated uveitis, toxoplasmosis retinochoroiditis) will have specific polymorphisms/mutations in innate immune system genes which predispose the patient to infectious uveitis.

Study contacts

Contact information is provided by the study sponsor or research team.

Kimberly M Baynes, BSN, RN, COA

CONTACT

[email protected]

216-444-2566

Sponsors and collaborators

Lead sponsor

The Cleveland Clinic

Other

Registry information

Important dates

Study start: 2011
Primary completion: 2030
Study completion: 2030
First posted: Feb 6, 2015
Registry last updated: Mar 4, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed