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OpenTrials
Completed

NCT Number: NCT03007043

Genetic Variation in Gonadotropin and Gonadotropin Receptor Genes and Suboptimal Response

To evaluate the difference in the prevalence of the main FSHR polymorphism (ASN680Ser), as well as other, less studied, gonadotropin polymorphisms between ovarian response groups, following ovarian stimulation

Completed

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Key information

Conditions

Fertility Disorders

Age range

18 year–38 year

Sex eligibility

Female

Study type

Observational

Primary location

Dexeus Salud de la Mujer, Barcelona, Spain

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Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age between 18-38 years old
  • BMI 18-28
  • Antral follicle count (AFC) > 9 or Anti-mullerian hormone (AMH) >1.1 ng/ml
  • 1st or 2nd ovarian stimulation cycle for IVF/ICSI
  • Planned to undergo ovarian stimulation with 150IU of rFSH in a fixed GnRH antagonist protocol

Exclusion criteria

  • Antral follicle count (AFC) <9 and AMH<1.1 ng/ml
  • PCOS patients according to the Rotterdam criteria
  • Patients undergoing in vitro maturation (IVM)
  • Untreated endocrine abnormalities

Treatment and study plan

blood sample

Other

Primary outcomes

  1. prevalence of the main FSH receptor polymorphism

    Time frame: 12 months

Sponsors and collaborators

Lead sponsor

Fundacion Dexeus

Other

Registry information

Official study title

Genetic Variation in Gonadotropin and Gonadotropin Receptor Genes as a Causative Factor of Suboptimal Response Following Ovarian Stimulation for IVF/ICSI. A Prospective Cohort Study

Important dates

Study start
2016
Primary completion
2019
Study completion
2019
First posted
Dec 30, 2016
Registry last updated
Jan 27, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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