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Completed

NCT Number: NCT02841501

Genetic Susceptibility Factors for Candidemia.

This is a prospective case-control physiopathological study, which main objective is to determine the genetic host factors predisposing to candidemia. Secondary objectives are to develop new diagnosis tools using the biological collection, to describe and update epidemiology, to analyse the influence of genetic polymorphisms on prognosis.

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Key information

Conditions

Invasive Candidiasis Bacterial Infections and Mycoses Candidemia Candidiasis Candidiasis, Invasive Disease Attributes Disease Susceptibility Fungemia Genetic Predisposition to Disease Infections Inflammation Invasive Fungal Infections Mycoses Pathologic Processes Pathological Conditions, Signs and Symptoms Sepsis Systemic Inflammatory Response Syndrome

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Hôpital Salengro, Intensive care departement, CHRU

Lille, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patient older than 18 years.
  • Informed consent.
  • Positive blood culture with isolation of Candida sp.

Exclusion criteria

  • No informed consent.
  • Patient younger than 18.
  • No insurance coverage.

Treatment and study plan

Analysis of genetic polymorphisms

Genetic

An analysis of the SNPs (single nucleotide polymorphism) of 25 candidate genes will be performed. This analysis will be completed by a genome wide association study.

Primary outcomes

  1. Frequency of the polymorphisms between the groups

    Time frame: In the 48-72 hours following the positive blood culture

Sponsors and collaborators

Lead sponsor

University Hospital, Lille

Other

Collaborators

  • Seventh Framework Programme
  • University of Lausanne Hospitals

Registry information

Official study title

Genetic Susceptibility Factors Involved in Candidemia: Case-control Study.

Important dates

Study start
2013
Primary completion
2020
Study completion
2020
First posted
Jul 22, 2016
Registry last updated
Mar 26, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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