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Completed

NCT Number: NCT04786054

Genetic Association of Glucocorticoid Receptor Gene Polymorphisms With Binge Eating

The aim of the present study was to specifically screen obese diabetic adolescent female individuals for BED, checking the variants of the GR gene (rs56149945; rs41423247) amongst identified individuals, and this led to assessing the impact of binge eating disorders on glycaemic control in obese diabetic adolescent females in Pakistan, South Asia.

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Key information

Conditions

Binge-Eating Disorder Adolescent Behavior Behavior Body Weight Diabetes Mellitus Diabetes Mellitus, Type 2 Diabetes Type 2 Eating Disorders Endocrine System Diseases Feeding and Eating Disorders Glucose Metabolism Disorders Mental Disorders Metabolic Diseases Nutrition Disorders Nutritional and Metabolic Diseases Obesity Overnutrition Overweight Pathological Conditions, Signs and Symptoms Signs and Symptoms Signs and Symptoms, Digestive

Age range

10 year–19 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Zainab Khan

Lahore, Punjab Province, Pakistan

About this study

Challenges in eating for diabetic adolescents can be categorized as eating disorders (ED) and disordered eating symptoms (DES). Binge-eating disorder (BED) is defined as recurrent episodes of binge eating at least once a week over a three-month time period and it is accompanied by feeling the lack of control and marked distress over one's eating behaviour. The aim of the present study was to specifically screen obese diabetic adolescent female individuals for BED, checking the variants of the GR gene (rs56149945; rs41423247) amongst identified individuals, and this led to assessing the impact of binge eating disorders on glycaemic control in obese diabetic adolescent females in Pakistan, South Asia.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Unmarried females diagnosed with Type 2 diabetes > 12 months
  • Age 10-19 years
  • Obesity class I and II (based on BMI range of 30 - 40).

Exclusion criteria

  • Presence of psychosis, major psychiatric or neurocognitive disorder
  • Substance use
  • Untreated attention-deficit hyperactivity disorder
  • Use of psychopharmacological medications or psychotherapy
  • Class III obesity

Treatment and study plan

BED Questionnaire

Diagnostic Test

BED Questionnaire

Primary outcomes

  1. BED

    Time frame: Baseline

    Presence of BED detected by individuals who score high on the BEDS7 Questionnaire administered

Secondary outcomes

  1. NR3C1 Presence of variants of the GR gene (rs56149945; rs41423247)

    Time frame: Six months into the study after identifying all individuals who scored high on the BEDS7 Questionnaire

    Presence of variants of the GR gene (rs56149945; rs41423247)

Sponsors and collaborators

Lead sponsor

Corporacion Parc Tauli

Other

Registry information

Official study title

Genetic Association of Glucocorticoid Receptor Gene Polymorphisms With Binge Eating Disorders in Type 2 Diabetic Obese Female Adolescents

Important dates

Study start
2019
Primary completion
2021
Study completion
2021
First posted
Mar 8, 2021
Registry last updated
Mar 9, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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