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Completed

NCT Number: NCT06602973

Relationships Between Exercise and Appetite in Women With Loss of Control Eating

This pilot study is a first step in looking at the relationship between exercise and appetite in women with loss of control eating.

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Key information

Conditions

Eating Disorders Behavior Binge-Eating Disorder Bulimia Nervosa Feeding and Eating Disorders Mental Disorders Motor Activity Pathological Conditions, Signs and Symptoms Signs and Symptoms Signs and Symptoms, Digestive

Age range

18 year–45 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Ohio University

Athens, Ohio, 45701, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Engage in loss of control eating at least 12 times in the last three months
  • Clinically significant eating disorder-related impairment (CIA > 15)
  • Minimum VO2max of 50th percentile for age and sex assigned at birth
  • Be willing to eat study-provided foods
  • Likes chocolate (at least 6/10 on 10 point scale)

Exclusion criteria

  • BMI < 18.5 kgm/2
  • Medical conditions that affect appetite or weight (e.g., diabetes mellitus, thyroid disease)
  • Recent pregnancy or breastfeeding (prior 6 months)
  • Relevant food allergies (e.g., wheat, chocolate)
  • Specific phobia, blood-injection-injury type
  • Medical condition that precludes safe participation in exercise (e.g., stress fracture)
  • Medications that acutely affect appetite (e.g., GLP-1 agonists; psychiatric medications allowed)

Treatment and study plan

Rest

Behavioral

Participants will eat breakfast but abstain from exercise

Fed Exercise

Behavioral

Participants will eat breakfast and engage in 30 minutes of physical activity at 75% of their personal V02max.

Fasted Exercise

Behavioral

Participants will engage in 30 minutes of physical activity at their personal 75% V02max after abstaining from breakfast.

Primary outcomes

  1. Relative Energy Intake

    Time frame: Food intake from 8 am to 8 am; Energy expenditure from approximately 9 am to 9:05 am and 9:25 to 9:30 am, coinciding with study condition (rest or exercise)

    Relative energy intake for 24 hours will be calculated as absolute energy intake from the breakfast (if consumed), lunch, food reward value task, and take home cooler minus energy expenditure during exercise (or comparable time period during rest).

Secondary outcomes

  1. Lactate

    Time frame: 30 minutes, pre-post exercise (or rest)

    Lactate values

  2. Acylated ghrelin

    Time frame: Immediately prior to lunch

    Acylated ghrelin

  3. Self-reported binge eating

    Time frame: 24 and 48 hours after exercise/rest study visit

    Participants will rate the extent the following questions, considering the time frame "since yesterday morning at 8 am" on a 1 to 5 scale from "not at all" to "extremely":

    "While you were eating, to what extent did you feel a sense of loss of control?," "While you were eating, to what extent did you feel that you could not resist eating," "While you were eating, to what extent did you feel that you could not stop eating once you had started," and "While you were eating, to what extent did you feel driven or compelled to eat?" An answer of 4 or higher on any item will be categorized as binge eating present. Any reported binge eating on either day will be coded as binge eating being present

  4. Food reward value

    Time frame: Approximately 3:30 pm day of study visit

    Number of trials according to task developed by Bodell and Keel 2015

Sponsors and collaborators

Lead sponsor

Ohio University

Other

Registry information

Important dates

Study start
2024
Primary completion
2026
Study completion
2026
First posted
Sep 19, 2024
Registry last updated
Apr 30, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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