Skip to main content
OpenTrials
Completed

NCT Number: NCT01765816

Generation 100: Blood Volume and Cardiac Function in Healthy Aging

Hypothesis: Exercise will reduce morbidity and mortality rates in an elderly population. The extent of reduction will be intensity dependent.

As part of the "Generation 100" study, this sub-study project will investigate the effect of exercise on blood volume, cardiopulmonary health and heart function in healthy aging. Objective is to determine the acute effect of one endurance training session on blood volume in healthy elderly. The working hypothesis is that one interval training session increases total blood volume by 10% in healthy elderly, and that there will be no change after moderate continuous training.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Ageing Behavior Motor Activity

Age range

70 year–75 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Norwegian University of Science and Technology

Trondheim, 7006, Norway

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • ability to walk at least 1km,
  • born in 1938,1939,1940,1941 or 1942
  • Sufficiently good health to be able to take part in the study, as determined by the researchers

Exclusion criteria

  • Illness or disability that precludes exercise or hinders completion of the study
  • Uncontrolled hypertension
  • Symptomatic valve disease, hyper tropic cardio-myopathy or unstable angina
  • Active cancer
  • Test results indicating that study participation is unsafe
  • Inclusion in other studies conflicting with participation in this one

Treatment and study plan

High Intensity Interval Training

Behavioral

Moderate Intensity Training

Behavioral

Primary outcomes

  1. total blood volume

    Time frame: 24 hours

    carbon monoxide-rebreathing spirometry (Bayreuth, Germany)

Secondary outcomes

  1. hemoglobin volume

    Time frame: 24 hours

    carbon monoxide-rebreathing spirometry (Bayreuth, Germany)

Sponsors and collaborators

Lead sponsor

Norwegian University of Science and Technology

Other

Registry information

Official study title

Generation 100: How Exercise Affects Mortality and Morbidity in the Elderly: A Randomized Control Study

Important dates

Study start
2012
Primary completion
2014
Study completion
2014
First posted
Jan 10, 2013
Registry last updated
Sep 28, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.