Gene Polymorphism of IL17 and IL 23

rates are in such considerable amount among large population base. The pathogenesis of COVID-19 implicates a potent inflammatory response, involving a complex group of mediators including interleukins. These pleiotropic cytokines are secreted at the region of inflammation and released into the circulation by a variety of different cell types, including macrophages, lymphocytes, endothelial cells, epithelial cells during sepsis and acute organ injuries. There has recently found a number of studies reporting that the cytokine storms take part in the course of COVID-19

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Key information

Conditions

COVID-19 Respiratory Infection

Sex eligibility

All sexes

Study type

Observational

Primary location

Sohag University

Sohag, 82733, Egypt

About this study

Aim Of The Study

To evaluate if there is an association between the IL-17, IL-23 gene polymorphism in Patients With COVID 19 by real-time PCR
To measure the serum level of IL17 by ELISA in COVID 19 patients by ELISA.
To detect if there is an association between gene polymorphism of IL17 and IL23 and severity of a condition in patients with COVID 19 Study design: a cross-sectional study.

The blood samples will be collected from patient records in COVID19 isolation hospitals in sohag governorate and isolation department in sohag university hospitals.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients with Covid19 positive PCR

Exclusion criteria

Patients with Covid19 clinical criteria not confirmed by PCR

Treatment and study plan

Laboratory test

Diagnostic Test

genotyping of IL 17 and IL23

Primary outcomes

genotyping of IL 17

Time frame: 3-6-2021 to 30-8-2021

real time pcr detection of different genotypes
genotyping of IL 23

Time frame: 3-6-2021 to 30-8-2021

real time pcr detection of different genotypes
estimation of serum level of IL 17

Time frame: 3-6-2021 to 30-8-2021

measuring serum level of IL 17 by ELISA

Sponsors and collaborators

Lead sponsor

Sohag University

Other

Registry information

Official study title

Association Between Gene Polymorphism of IL17 and IL 23 in Patients With COVID 19

Acronym: COVID 19IL17

Important dates

Study start: 2021
Primary completion: 2021
Study completion: 2021
First posted: Jul 2, 2021
Registry last updated: Oct 25, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

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