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Recruiting

NCT Number: NCT07398209

GCC 2546- Motion Management

The purpose of this study is to assess a real time motion tracking of lung tumors and important organs next to the tumor while breathing during a participant's radiation treatment. This will be assessed through a four-dimensional magnetic resonance imaging (MRI) scan before starting your radiation treatment and x-ray fluoroscopy images that are taken during radiation

Recruiting

Interested in participating?

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Key information

Conditions

Lung Cancer (NSCLC) Bronchial Neoplasms Carcinoma, Bronchogenic Carcinoma, Non-Small-Cell Lung Lung Diseases Lung Neoplasms Neoplasms Neoplasms by Site Radiation Respiratory Tract Diseases Respiratory Tract Neoplasms Thoracic Neoplasms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Maryland Greenebaum Cancer Center

Baltimore, Maryland, 21201, United States

Location status: Recruiting

Location contact

Caitlin Eggleston, MPH

CONTACT

[email protected]

410-369-5351

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adult (≥18 years) patients (both sexes) with histologically diagnosed Stage II-IIIb NSCLC
  • Patients to be treated with definitive external beam photon radiotherapy with or without systemic therapy (e.g., chemotherapy, immunotherapy).
  • No restrictions on number radiotherapy fractions, or location/number of lesions
  • ECOG performance status ≤ 3
  • Ability to undergo MRI scans
  • Patient has signed informed consent document and agreed to study procedures

Exclusion criteria

  • Pre-existing contraindications for MRI, such as any MRI-conditional or MRI-unsafe foreign objects within the body, non-removable ear cochlear or eye implant, aneurysm clip, cardiac pacemaker/wires, internal defibrillator, tissue expander, recent stent placement, penile prosthesis, medication patch, artificial limb, pregnancy, and claustrophobia
  • Women who are pregnant or trying to get pregnant (self-reported)
  • Pain in supine position or inability to raise arm above head in supine position

Treatment and study plan

MRI

Other

Baseline 4D CT Simulation and 4S MRI with surface monitoring through EndoScout vest, followed by fluoroscopy and additional surface monitoring while undergoing daily radiation.

Other names: Fluoroscopy, Surface Monitoring

Primary outcomes

  1. To investigate if time-resolved, multicycle volumetric motion modeling and monitoring gives improved spatiotemporal localization of the tumor target and OARs compared to current standard-of-care 4DCT-based motion modeling and monitoring

    Time frame: 3 years

Study contacts

Contact information is provided by the study sponsor or research team.

Amit Sawant, PhD

CONTACT

[email protected]

410-328-6080

Caitlin Eggleston, MPH

CONTACT

[email protected]

410-369-5351

Sponsors and collaborators

Lead sponsor

University of Maryland, Baltimore

Other

Registry information

Official study title

Combining 4D MRI and 4DCT for Personalized Volumetric Motion Monitoring in Lung Radiation Therapy

Important dates

Study start
2026
Primary completion
2028
Study completion
2029
First posted
Feb 9, 2026
Registry last updated
Jun 26, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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