GCC 2545- Improving Post-Radiotherapy Respiratory Function Through Sparing Serial and Parallel Components in the Lung

Inclusion criteria

• Step 1- Inclusion Criteria

• Adult (≥18 years) patients (both sexes) with histologically diagnosed Stage III NSCLC per AJCC ver 9
• Patients to be treated with definitive external beam photon radiotherapy with or without systemic therapy (e.g., chemothrapy, immunotherapy).
• No restrictions on number radiotherapy fractions, or location/number of lesions
• ECOG performance status ≤ 3
• Ability to hold breath for ≥ 15 seconds
• Patient has signed informed consent document and agreed to study procedures

Step 2- Inclusion Criteria 1. Patient has completed 4DCT and BHCT with subsequent plans created and Radiation Oncologist has determined that patient would benefit from INSPIRE RT.

Exclusion criteria

• Step 1- Exclusion Criteria

• Prior lung cancer-directed radiotherapy
• Recent (< 12 mo) or planned lung surgery (which would confound pre- and post-RT lung function measures)
• Patients with metal implants or metal stents in the thoracic region
• Known severe chronic obstructive pulmonary disease or interstitial lung disease
• Women who are pregnant or trying to get pregnant

Step 2- Exclusion Criteria

• Patient found to not benefit from INSPIRE RT after comparison of treatment plans.