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OpenTrials
Completed

NCT Number: NCT04067154

Gas Exchange and CT Effects of PEEP in ARDS

The study aims to investigate the association between effects of PEEP on gas exchange model parameters and CT scan results

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Key information

Conditions

ARDS

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico

Milan, MI, 20122, Italy

About this study

In ARDS patients on mechanical ventilation, we will compare model-based estimation of gas exchange parameters (shunt, ventilation/perfusion mismatch) with CT-based estimation of effects of low and high PEEP

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • ARDS patients requiring mechanical ventilation

Exclusion criteria

  • <18 years old
  • Requirement of extracorporal life support
  • Hemodynamic instability
  • Barotrauma

Treatment and study plan

ALPE

Diagnostic Test

Measurement of CT scan at PEEP of 5, 20 and 45 cm H2O Measurement of gas exchange by model-based method and FiO2 titration at PEEP of 5 and 20 cm H2O

Primary outcomes

  1. Gas Exchange and lung recruitability at diferent PEEP levels

    Time frame: Approximately two hours

    Gas exchange (At PEEP 5 and 20 cm H2O), CT scan (At PEEP 5, 20 and 45 cm H2O)

Secondary outcomes

  1. Physiologic Parameter 1

    Time frame: Approximately two hours

    Hemodynamic assessment at different PEEP levels

  2. Physiologic Parameter 2

    Time frame: Approximately two hours

    Respiratory mechanics at different PEEP levels

Sponsors and collaborators

Lead sponsor

Policlinico Hospital

Other

Registry information

Official study title

Does a Bedside Method for Describing Functional Gas Exchange Compare Well With Anatomical Description Via CT Scans, and Could it Predict the Effects of Recruitment and Ventilation/Perfusion Mismatch Improvement

Important dates

Study start
2012
Primary completion
2014
Study completion
2014
First posted
Aug 26, 2019
Registry last updated
Aug 26, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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