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Completed

NCT Number: NCT07267182

Gabapentin and Diclofenac Sodium Comparison for Post-Operative Pain Relief

Little is known about comparative efficacy of gabapentin and diclofenac sodium in managing post-operative pain. Therefore, this study was planned to compare the efficacy of gabapentin, and diclofenac sodium for post-operative pain relief in patients undergoing major abdominal surgeries.

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Key information

Conditions

Postoperative Pain Neurologic Manifestations Pain Pain, Postoperative Pathologic Processes Pathological Conditions, Signs and Symptoms Postoperative Complications Signs and Symptoms

Age range

18 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Bahawal Victoria Hospital

Bahawalpur, Punjab Province, 63100, Pakistan

About this study

Non-steroidal anti-inflammatory drugs, opioid analgesics, and local and regional anesthesia have been used as preventive interventions, but their role in postoperative pain management remains inconclusive. Gabapentin is a relatively new drug for postoperative pain management whose side effects are well tolerated. If the findings of this study produce similar observations, it would add to the already scarce data and help patients undergoing major abdominal surgeries in the local settings in relieving postoperative pain effectively.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Any gender
  • Aged 18-60 years
  • Undergoing elective major abdominal surgery under general anesthesia
  • With physical status I or II
  • Who were able to comprehend and use the Visual Analogue Scale (VAS) for pain assessment

Exclusion criteria

  • With a known allergy or contraindication to gabapentin, or diclofenac sodium
  • A history of peptic ulcer disease
  • A history of gastrointestinal bleeding
  • Hepatic or renal dysfunction
  • Pregnancy or lactation
  • With neurological or psychiatric disorders affecting pain perception
  • Received opioids, anticonvulsants, antidepressants, or nonsteroidal anti-inflammatory drugs (NSAIDs) within 24 hours before surgery
  • With uncontrolled hypertension, ischemic heart disease, or diabetes mellitus
  • Those who experienced intraoperative complications necessitating a change in anesthetic plan or postoperative mechanical ventilation

Treatment and study plan

Gabapentin 600mg

Drug

Patients received a single oral dose of gabapentin 600 mg one hour before surgery.

Diclofenac Sodium 100 MG

Drug

Patients were given a single oral dose of diclofenac sodium 100 mg one hour before surgery.

Primary outcomes

  1. Pain reduction

    Time frame: 12 hours

    Patients were considered to have effective pain relief ("Yes") if their VAS score remained ≤3 throughout the monitoring period without requiring rescue analgesia.

Sponsors and collaborators

Lead sponsor

Muhammad Aamir Latif

Other

Registry information

Official study title

Comparative Efficacy of Gabapentin and Diclofenac Sodium for Post-Operative Pain Relief in Patients Undergoing Major Abdominal Surgeries

Important dates

Study start
2022
Primary completion
2023
Study completion
2023
First posted
Dec 5, 2025
Registry last updated
Dec 5, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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