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NCT Number: NCT07675343

Functional Progressive Resistive Training and Cerebral Palsy

Functional Progressive Resistive Exercise (FPRE) is a strengthening approach that combines functional movement activities with progressively increased resistance. It involves performing task-oriented exercises, such as sit-to-stand, stair climbing, and walking-related activities, while gradually increasing the load to enhance muscle strength, endurance, and functional performance. FPRE is widely used in rehabilitation programs to improve mobility and the ability to perform activities of daily living in various populations, including children with neurological and musculoskeletal disorders.

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Key information

Age range

6 year–10 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • A diagnosis of spastic diplegic CP
  • Degree of spasticity ranges from 1+ and 2, according to modified Ashworth scale (MAS)
  • The age of the selected children will range from 6 to 10 years old.
  • Children are levels II and III according to GMFCS

Exclusion criteria

1 - Children with visual or auditory problems. 2. Children with severe intellectual disability (IQ less than 65 according to Stanford Binet intelligence scale).

Treatment and study plan

functional progressive resistive exercise and designed physical therapy program

Other

specially designed physical therapy program in addition to functional progressive resistive exercises for 60 min (30 min designed P.T program and other 30 min for brain gym exercises), 3 sessions/ week for 3 successive months. 6 functional progressive resistive exercises will be selected:

  • Sit-to-Stand Exercise
  • Step-Up Exercise
  • Squats
  • Lunges
  • Stair Climbing
  • Loaded Walking

Designed physical therapy program

Other

conventional physical therapy program including reinforcement of the normal motor development, reflex inhibiting patterns, postural reaction, stretching, strengthening exercises, and gait training was applied to children in the control group

Primary outcomes

  1. Dual-energy X-ray absorptiometry (DXA)

    Time frame: 3month

    The most common test for bone mineral density is a Dual-energy X-ray absorptiometry (DXA) scan. It is:

    Painless and non-invasive Quick (usually 10-20 minutes) Low radiation exposure Most often performed on the hip and lower spine. Bone mineral density (BMD) is a measure of the amount of mineral (mainly calcium and phosphorus) present in a specific volume of bone. It reflects bone strength and is used to assess the risk of fractures and diagnose osteoporosis.

  2. biodex balance system

    Time frame: 3 month

    The Biodex Balance System is a computerized device used to assess and improve static and dynamic balance, postural stability, and neuromuscular control. It consists of a movable platform that can be adjusted to different levels of stability, allowing clinicians and researchers to evaluate an individual's ability to maintain balance under varying conditions.

Study contacts

Contact information is provided by the study sponsor or research team.

Alaa Alnemr

CONTACT

[email protected]

+201003727467

Sponsors and collaborators

Lead sponsor

Cairo University

Other

Registry information

Official study title

Effect of Functional Progressive Resistance Training on Bone Mineral Density and Balance in Children With Cerebral Palsy

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Jun 30, 2026
Registry last updated
Jun 30, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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