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OpenTrials
Completed

NCT Number: NCT00864461

Frequency of Metabolic Syndrome in Down Syndrome Patients

The aim of this study is to assess the frequency of metabolic syndrome in Down syndrome patients because the prevalence of diabetes mellitus and obesity is higher in individuals with Down syndrome than in the general population.

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Key information

Conditions

Metabolic Syndrome X Abnormalities, Multiple Chromosome Disorders Congenital Abnormalities Congenital, Hereditary, and Neonatal Diseases and Abnormalities Down Syndrome Genetic Diseases, Inborn Glucose Metabolism Disorders Hyperinsulinism Insulin Resistance Intellectual Disability Metabolic Diseases Metabolic Syndrome Nervous System Diseases Neurobehavioral Manifestations Neurologic Manifestations Nutritional and Metabolic Diseases

Age range

7 year–24 year

Sex eligibility

All sexes

Study type

Observational

Primary location

School of Medicine, University of Guanajuato

León, Guanajuato, 37320, Mexico

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Clinical diagnosis of Down syndrome

Exclusion criteria

  • History of congenital cardiac defects requiring open-heart surgery
  • History of gastroenterologic anomalies requiring bowel resection and/or ongoing medical intervention
  • History of leukemia or other cancer
  • History of hypothyroidism requiring thyroid hormone replacement

Treatment and study plan

Primary outcomes

  1. To asses the frequency of the metabolic syndrome among Down syndrome patients. Metabolic syndrome was defined by Adult Treatment Panel III criteria modified by Halley-Castillo.

    Time frame: One year

Secondary outcomes

  1. Evaluate the insulin resistance and insulin sensitivity using the HOMA and QUICKY methods.

    Time frame: One year

Sponsors and collaborators

Lead sponsor

Universidad de Guanajuato

Other

Registry information

Official study title

Prevalence of Metabolic Syndrome in Down Syndrome Patients

Important dates

Study start
2009
Primary completion
2009
Study completion
2010
First posted
Mar 18, 2009
Registry last updated
May 5, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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