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NCT Number: NCT07099963

Frequency and Severity of Respiratory Acidosis During One-lung Ventilation, a Retrospective Pilot Study to Compare Clinician Settings and Those Proposed by the VentilO Application

One-lung ventilation is a mechanical ventilation method frequently used during several thoracic surgeries. One-lung ventilation requires the use of protective ventilation to limit ventilator-induced injury and reduce postoperative respiratory complications. Protective ventilation during one-lung ventilation is specific since tidal volumes are applied by definition to one lung, and it is recommended to use lower tidal volumes, down to 4 ml/kg of ideal body weight. This approach requires individualized ventilation parameters, which differs from the conventional or two-lung ventilation, and there are no clear recommendations regarding respiratory rate adjustment to ensure adequate gas exchange.

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Key information

Conditions

Thoracic Acid-Base Imbalance Acidosis Hypercapnia Mechanical Ventilation Metabolic Diseases Nutritional and Metabolic Diseases One Lung Ventillation (OLV) Pathological Conditions, Signs and Symptoms Signs and Symptoms Signs and Symptoms, Respiratory Smartphone Application Surgery

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Institut universitaire de cardiologie et de pneumologie de Québec - Université Laval

Québec, Quebec, G1V4G5, Canada

Location status: Recruiting

Location contact

Francois Lellouche

CONTACT

[email protected]

418-656-8711

About this study

The aim of the study is to:

  • Evaluate whether the initial ventilation settings (tidal volume and respiratory rate) during one-lung ventilation are appropriate to prevent respiratory acidosis.
  • Compare the ventilation settings (tidal volume and respiratory rate) made by clinicians with those proposed by an smartphone application ''VentilO''.

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adults (≥ 18 years old)
  • Patients intubated and undergoing one-lung ventilation during thoracic surgery
  • Volume-controlled ventilation mode used intraoperatively

Exclusion criteria

  • Arterial blood gas data unavailable during one-lung ventilation
  • Missing demographic data (sex, height, actual weight)

Treatment and study plan

One Lung Ventilation

Other

Arterial blood gases during one lung ventilation

Primary outcomes

  1. Respiratory acidosis

    Time frame: 20 minutes after initiation of one lung ventilation after lung isolation

    The frequency of respiratory acidosis on arterial blood gases after 20 minutes of mechanical ventilation (pH < 7.35 and PaCO2 > 45mmHg) measured by arterial blood gases

Secondary outcomes

  1. Respiratory rate

    Time frame: At the beginning of one lung ventilation during the surgery

    Respiratory rate set by the doctor, this respiratory rate will be compared to the suggestion of the algorithm

  2. Acid-base disorder

    Time frame: At the beginning of one lung ventilation during the surgery

    Presence of Respiratory alkalosis define by pH>7.45 and PaCO2 < 35 mmHg

  3. Number of participants with hemodynamic shock - hypotension

    Time frame: Day 1

    Requiring >1L of volume repletion and/or use of amines at >0.05 mcg/kg/min or norepinephrine equivalent

  4. Hospital length of stay

    Time frame: Up to 90 days

    Recovery room admission through hospital discharge

  5. Mechanical Ventilation duration

    Time frame: Up to 90 days

    Time spent with invasive mechanical ventilation during surgery and hospital stay

  6. Hospital mortality

    Time frame: Up to 90 days

    Occurence of death during hospital stay

Study contacts

Contact information is provided by the study sponsor or research team.

Francois Lellouche

CONTACT

[email protected]

1-418-656-8711

Sponsors and collaborators

Lead sponsor

Laval University

Other

Registry information

Important dates

Study start
2025
Primary completion
2025
Study completion
2026
First posted
Aug 1, 2025
Registry last updated
Aug 6, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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