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NCT Number: NCT06508190

Free Walking Exercise in Obstructive Sleep Apnea Patients With Non-alcoholic Fatty Liver

Research evaluating the impact of continuous positive airway pressure (CPAP) & walking exercise on fatigue severity, liver enzymes and sleeping quality in patients with non-alcoholic fatty liver disease who also have obstructive sleep apnea. Forty patients are divided into two groups: twenty patients CPAP and other twenty patients for CPAP and walking program .

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Key information

Conditions

Obstructive Sleep Apnea Apnea Digestive System Diseases Dyssomnias Fatty Liver Liver Diseases Nervous System Diseases Non-alcoholic Fatty Liver Non-alcoholic Fatty Liver Disease Respiration Disorders Respiratory Tract Diseases Sleep Apnea Syndromes Sleep Apnea, Obstructive Sleep Disorders, Intrinsic Sleep Wake Disorders

Age range

40 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Ahram canadian university

Giza, Egypt

Location status: Recruiting

Location contact

hagar El-Hadidy, lecturer

CONTACT

[email protected]

About this study

Research evaluating the impact of continuous positive airway pressure (CPAP) & walking exercise on fatigue severity, liver enzymes and sleeping quality in patients with non-alcoholic fatty liver disease who also have obstructive sleep apnea. Forty patients are divided into two groups: twenty patients CPAP and other twenty patients for CPAP and walking program .

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • The body mass index (BMI) < 35 kg/m2.
  • obstructive sleep apnea patients with fatty liver

Exclusion criteria

  • liver transplantation , alcoholic fatty liver, antipsychotic medications, bariatric surgery; cardiac , renal problem , liver cancer ; pregnancy,orthopedic problems, systemic diseases, respiratory dysfunctions, neurological dysfunctions.

Treatment and study plan

continuous positive airway pressure

Behavioral

continuous positive airway pressure therapy for a period of 12 weeks, all patients with in this group are required to utilize the CPAP machine for at least 4 hours each night

free walking exercise and continuous positive airway pressure

Behavioral

patients will receive continuous positive airway pressure therapy for a period of 12 weeks, all patients with in this group are required to utilize the CPAP machine for at least 4 hours each night. Also, patients will perform walking exercise for 30 mint, daily for 12 weeks

Primary outcomes

  1. Alanine tranaminase

    Time frame: it will be measured after 12 weeks

    serum hepatic enzyme

Secondary outcomes

  1. Asparatate transamianse

    Time frame: it will be measured after 12 weeks

    serum hepatic enzyme

  2. Body mass index

    Time frame: it will be measured after 12 weeks

    it will be masusured on empty stomach and bladder

  3. triglycerodes

    Time frame: it will be assessed after 12 weeks

    it will be meausred in plasma

  4. Pittsiburg sleeping quality index

    Time frame: it will be assessed after 12 weeks

    a questionnaire that wil be used for assessing sleeping quality

  5. fatigue severity scale

    Time frame: it will be assessed after 12 weeks

    a questionnaire that wil be used for assessing fatigue

  6. Epworth sleepness scale

    Time frame: it will be assessed after 12 weeks

    a questionnaire that wil be used for daytime sleepness

Study contacts

Contact information is provided by the study sponsor or research team.

El-Hadidy Hagar, PHD

CONTACT

[email protected]

00201007453552

El-gohary Ola, PHD

CONTACT

01227191398

Sponsors and collaborators

Lead sponsor

Ahram Canadian University

Other

Registry information

Official study title

Impact of Free Walking Exercise on Obstructive Sleep Apnea Patients With Non-alcoholic Fatty Liver on Liver Enzymes, Degree of Exhaustion, and Quality of Sleep

Important dates

Study start
2024
Primary completion
2024
Study completion
2024
First posted
Jul 18, 2024
Registry last updated
Jul 18, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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