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OpenTrials
Completed

NCT Number: NCT00730873

Fatty Liver and Obstructive Sleep Apnea

Non-alcoholic fatty liver disease is associated with obstructive sleep apnea. Abnormalities in liver enzymes can improve following continuous positive airway pressure in patients with obstructive sleep apnea. Computerized tomography can be used to quantify fatty liver changes. We hypothesize that continuous positive airway pressure can reduce morphologic fatty liver changes in patients with obstructive sleep apnea and non-alcoholic fatty liver, an that this reduction can be evident using computerized tomography

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Key information

Conditions

Non-Alcoholic Fatty Liver Disease Apnea Digestive System Diseases Dyssomnias Fatty Liver Liver Diseases Nervous System Diseases Obstructive Sleep Apnea Respiration Disorders Respiratory Tract Diseases Sleep Apnea Syndromes Sleep Apnea, Obstructive Sleep Disorders, Intrinsic Sleep Wake Disorders

Age range

30 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

The pulmonary institute, Asaf Harofeh Medical Center

Ẕerifin, 70300, Israel

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Obstructive sleep apnea, defined as AHI>5/h

Exclusion criteria

  • Consumption of more than 20 grams of alcohol per 24 h
  • Known autoimmune disease
  • Usage of known hepatotoxic drugs
  • Medical history positive for viral hepatitis or other chronic liver disease

Treatment and study plan

Continuous Positive Airway Pressure

Device

Primary outcomes

  1. Reduction in fatty liver changes on computerized tomography

    Time frame: Within 1-2 years

Secondary outcomes

  1. Improved liver enzymes abnormalities

    Time frame: Within 1-2 years

Sponsors and collaborators

Lead sponsor

Assaf-Harofeh Medical Center

Other Gov

Registry information

Important dates

First posted
Aug 8, 2008
Registry last updated
Aug 8, 2008

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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