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NCT Number: NCT07181096

Frailty Among Renal Transplant Recipients and Relation to Chronic Allograft Dysfunction

The aim of the study is to assess prevalence of frailty among renal transplant recipients in Alexandria University Hospitals and to study the relation between frailty and chronic allograft dysfunction.

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Key information

Conditions

Frailty Pathologic Processes Pathological Conditions, Signs and Symptoms Renal Transplant

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Faculty of Medicine, Aexandria University

Alexandria, 21526, Egypt

Location status: Recruiting

Location contact

mohamed mamdouh elsayed, MD

CONTACT

[email protected]

00201068055103

About this study

With respect to correlates of frailty, although higher comorbidity burden is also a risk factor for frailty among KT candidates, frailty can also occur in the setting of lower comorbidity burdens. Diabetes and serum albumin concentration are also associated with frailty among prevalent dialysis patients.

In addition, individuals with CKD and ESKD who are frail are also more likely to have cognitive impairment and sarcopenia, or low muscle mass, than their non-frail counterparts

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Renal transplanted patients with GFR more than 30

Exclusion criteria

  • Mentally or physically unfit patients.
  • Amputation of lower limb.
  • Active neoplasia, chronic liver disease, previous immunological disease.
  • Psychiatric disorders.
  • Pregnancy.

Treatment and study plan

assessment of frailty

Diagnostic Test

This study is a prospective cross-sectional study to assess the prevalence of frailty among 80 cases of renal transplanted patients.

Specific tests will include:

  • Assessment of frailty by Clinical Frailty Scale.
  • Assessment of nutritional status using Patient Generated Subjective Global Assessment (PG-SGA).
  • Comorbidity assessment using Charlson comorbidity score.
  • Six minutes walk test.
  • Muscle strength assessment using hand grip strength (HGS) dynamometer.

Primary outcomes

  1. Assessment of frailty

    Time frame: 30 days

    by Clinical Frailty Scale.

Secondary outcomes

  1. Assessment of nutritional status

    Time frame: 30 days

    using Patient Generated Subjective Global Assessment (PG-SGA)

  2. Comorbidity assessment

    Time frame: 30 days

    using Charlson comorbidity score

  3. Muscle strength assessment

    Time frame: 30 days

    using hand grip strength (HGS) dynamometer.

Study contacts

Contact information is provided by the study sponsor or research team.

Mohamed mamdouh Elsayed, MD

CONTACT

[email protected]

00201068055103

Sponsors and collaborators

Lead sponsor

Alexandria University

Other

Registry information

Official study title

Study of Frailty Among Renal Transplant Recipients, Its Relation to Chronic Renal Allograft Dysfunction

Important dates

Study start
2025
Primary completion
2025
Study completion
2026
First posted
Sep 18, 2025
Registry last updated
Sep 18, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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