Focused Ultrasound Thalamotomy for Tremor Relief in Atypical Parkinsonism

The goal of this retrospective observational study is to describe the efficacy of focused ultrasound ventral-intermediate nucleus thalamotomy in patients with atypical parkinsonism.

* Is this treatment efficacious in patients with multiple system atrophy? * Is this treatment efficacious in patients with diffuse Lewy Body Dementia? Data will be collected from patients charts.

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Key information

Conditions

Atypical Parkinsonism Autonomic Nervous System Diseases Basal Ganglia Diseases Brain Diseases Central Nervous System Diseases Dementia Dementia With Lewy Bodies Dyskinesias Lewy Body Disease Mental Disorders Movement Disorders Multiple System Atrophy Multiple System Atrophy, MSA Nervous System Diseases Neurocognitive Disorders Neurodegenerative Diseases Neurologic Manifestations Parkinsonian Disorders Pathological Conditions, Signs and Symptoms Primary Dysautonomias Signs and Symptoms Synucleinopathies Thyroid Dyshormonogenesis 2A Tremor

Sex eligibility

All sexes

Study type

Observational

Primary location

Rambam Health Care Campus

Haifa, 3109601, Israel

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion Patients that underwent FUS ventral-intermediate nucleus thalamotomy Suffer from multiple system atrophy-Parkinsonian type (MSA-P) or dementia with Lewy bodies (DLBD).

Exclusion criteria

Patients that did not underwent FUS ventral-intermediate nucleus thalamotomy
Patients that underwent FUS ventral-intermediate nucleus thalamotomy and do not suffer from MSA or DLBD

Treatment and study plan

Data Collection

Other

Data collection

Primary outcomes

Clinical Rating Scale for Tremor

Time frame: baseline, pre-procedure, 1 month, 6 months and 1 year following procedure

tremor assessment by Clinical Rating Scale for Tremor. Scores ranging from 0 to 156, with higher scores indicating more severe tremor.

Sponsors and collaborators

Lead sponsor

Rambam Health Care Campus

Other

Registry information

Acronym: FUSAP

Important dates

Study start: 2013
Primary completion: 2023
Study completion: 2023
First posted: Jan 12, 2024
Registry last updated: Jan 12, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed