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Completed

NCT Number: NCT05414097

Finding Barriers and Designing Solutions to Promote Women s Cancer Screening in South Africa

The primary aim of the study explore drivers of cervical cancer screening and barriers contributing to low screening coverage among women in South Africa. Secondary aims are determining preferences for cervical cancer prevention services using a discrete choice experiment and developing a multi-level package of interventions that will address barriers to cervical cancer screening and improve engagement in care among women.

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Key information

Conditions

Cervical Cancer Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Genital Diseases Genital Diseases, Female Genital Neoplasms, Female Neoplasms Neoplasms by Site Urogenital Diseases Urogenital Neoplasms Uterine Cervical Diseases Uterine Cervical Neoplasms Uterine Diseases Uterine Neoplasms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Clinical HIV Research Unit Temba Lethu Wing Helen Joseph Hospital

Westdene, Johannesburg, 2092, South Africa

About this study

Cervical cancer is a leading cause of cancer death among South African women. Despite a comprehensive national cancer control policy, cervical screening coverage is low and attrition during on-ward referrals for diagnostic confirmation and treatment remains common.

This study uses a sequential mixed-methods design:

Phase 1) A qualitative exploratory phase using focus groups and in-depth interviews with women, men, other stakeholders will inform our design and interpretation of quantitative findings from a multi-cohort DCE.

Phase 2) Women will be recruited to participate in the DCE and determine their preferences for cancer screening services.

Phase 3) Design Thinking to co-create an intervention package for cervical cancer screening and enhanced linkage between screening, diagnosis, and treatment will be created.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Focus Groups with HIV-positive Women

  • HIV-positive
  • Women 18 years and older
  • Participants should be willing and able to provide written informed consent

Focus Groups with HIV-negative Women

  • HIV-negative
  • Women 18 years and older
  • Participants should be willing and able to provide written informed consent

Focus Groups with Men

  • Male partners who are 18 years and older
  • Participants should be willing and able to provide written informed consent

In-depth Interviews with Key Stakeholders

  • Healthcare providers working within the public health system and other key stakeholders
  • Individuals 18 years and older
  • Participants should be willing and able to provide written informed consent

Exclusion criteria

Focus Groups with HIV-positive Women

  • Women younger than 18 years
  • Unwilling or unable to provide written informed consent

Focus Groups with HIV-negative Women

  • Women younger than 18 years
  • Unwilling or unable to provide written informed consent

Focus Groups with Men

  • Male partners younger than 18 years
  • Participants unwilling or unable to provide written informed consent

In-depth Interviews with Key Stakeholders

  • Providers who do not work in the public health system
  • Individuals younger than 18 years
  • Participants unwilling or unable to provide written informed consent

Treatment and study plan

Semi-structured focus group discussions - Women

Other

Semi-structured focus group discussions to explore women's experiences with cervical cancer screening and treatment.

semi-structured focus groups discussions - Men

Other

Semi-structured focus group discussions to explore partner dynamics related to women's ability to access cancer screening.

In-depth key stakeholders interviews

Other

In-depth interviews to contextualise findings from women and men focus group discussions.

Discrete Choice Experiment - Women

Other

Discrete Choice Experiment to determine preferences to different cancer screening models.

Development and User Pre-testing Workshops

Other

Development and User Pre-testing Workshops to explore acceptability and feasibility of proposed interventions designed using findings from Phases 1 &2.

Primary outcomes

  1. Phase 1: Barriers to cancer screening and engagement

    Time frame: Single visit

    Barriers and enablers will be explored through focus groups and in-depth interviews with women, men, and other stakeholders.

Secondary outcomes

  1. Phase 2: Woman preferences for cancer screening services

    Time frame: Single visit

    Preferences for cancer screening will be determined through the relative importance of the attribute according on how it is scored in the Discrete Choice Experiment.

  2. Phase 3: Acceptability and feasibility of multi-level package of interventions addressing barriers to cancer screening.

    Time frame: Single visit

    Acceptability and feasibility will be measured through development and user pre-testing workshops.

Sponsors and collaborators

Lead sponsor

UNC Lineberger Comprehensive Cancer Center

Other

Collaborators

  • Fogarty International Center of the National Institute of Health

Registry information

Acronym: FIND

Important dates

Study start
2022
Primary completion
2023
Study completion
2023
First posted
Jun 10, 2022
Registry last updated
Apr 15, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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