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Completed

NCT Number: NCT06064786

Fetuin A Association in Periodontal Disease and Diabetes Mellitus

Aim: The aim of the current study was to compare and correlate gingival crevicular fluid (GCF) fetuin-A levels and high sensitivity C-reactive protein (hs-CRP) levels in non-diabetic periodontitis patients and type 2 diabetic periodontitis patients with healthy subjects and revealing its possible role in diagnosis of periodontal disease.

Methodology: Forty-five periodontitis stage III patients categorized into 3 groups according to whether having type II diabetes mellitus or not were compared to systemically and periodontally healthy participants in this investigation. Clinical parameters for all groups were recorded. Assessment of GCF levels of fetuin A and hs-CRP were done to all enrolled participants utilizing an enzyme linked immune-sorbent assay (ELISA) kit. Receiver operating characteristic (ROC) curve was performed to reveal sensitivity, specificity, predictive value and diagnostic accuracy of the markers used.

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Key information

Conditions

Periodontitis, Adult Chronic Disease Chronic Periodontitis Disease Attributes Mouth Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Periodontal Diseases Periodontitis Stomatognathic Diseases

Age range

20 year–60 year

Sex eligibility

All sexes

Study type

Observational

Primary location

faculty of dentistry, Fayoum university

Al Fayyum, Egypt

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • both gender periodontitis stage III

Exclusion criteria

  • Smoking,
  • Systemic diseases (except DM in group B),
  • Periodontitis patients having periodontal treatment recently (past 6 months),
  • Pregnancy, lactation, contraceptive pills,
  • Anti-inflammatory/ immunosuppressive drugs.

Treatment and study plan

GCF levels of fetuin A and hsCRP evaluation

Diagnostic Test

ELIZA kits are used for GCF levels of fetuin A and hsCRP evaluation

Primary outcomes

  1. GCF levels of fetuin A and hsCRP evaluation in all groups

    Time frame: levels of fetuin A and hsCRP are measured at baseline after the completion of all GCF sample collection carried at the day of enrollment of subjects in the investigation after diagnosis confirmation

    ELIZA kits

Sponsors and collaborators

Lead sponsor

Fayoum University

Other

Registry information

Official study title

Evaluation of Fetuin-A and hsCRP Levels in Gingival Crevicular Fluid in Periodontitis Diabetic and Non-Diabetic Patients

Important dates

Study start
2023
Primary completion
2023
Study completion
2023
First posted
Oct 3, 2023
Registry last updated
Oct 3, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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