Clinical Efficacy of NST With Adjunctive Local Delivery of Ozonated Olive Versus Curcumin Gel in Stage II Grade B Periodontitis.

Periodontitis is an advanced periodontal disease with a distinctive clinical signs and symptoms as rapid attachment loss and bone destruction

The primary treatment approach for periodontitis is mechanical plaque removal through debridement, particularly scaling and root planing (SRP) using hand or ultrasonic instruments.

curcumin gel is an adjunct to non-surgical periodontal therapy is a highly potent local antioxidant and anti-inflammatory agent. While ozone has a potent antimicrobial and anti-inflammatory effects it also can be incorporated into a lipid carrier such as olive oil. Ozone's stability and ease of application are markedly enhanced. Ozonized olive oil can be formulated into a gel with ideal rheological properties for injection into periodontal pockets.

Inclusion criteria

• Patients diagnosed with stage II periodontitis defined by having interdental CAL 3-4 mm and presence of pocket depth (PD) ≤ 5 mm, and grade B periodontitis characterized by a moderate rate of disease progression.
• Patients agree to a 3-month follow-up period and provide an informed consent.

Exclusion criteria

• Presence of prosthetic crowns, overhanging restorations and orthodontic treatment.
• Teeth with both endo-perio lesions.
• Antibiotics therapy that has an impact on the clinical signs and symptoms of periodontitis in the previous 3 months.
• Anti-inflammatory drugs in the previous 1 month.

• History of systemic disease, allergy, cardiovascular diseases, diabetes mellitus, hypertension, bleeding disorders, hyperparathyroidism, and compromised medical conditions, pregnant and lactating females.