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Completed

NCT Number: NCT06249893

Feasibility of Doppler Ultrasound for Pulse Detection in Out-of-Hospital Cardiac Arrest Patients

The goal of this prospective observational study is to investigate the feasibility of using doppler point-of-care ultrasound on the femoral artery with a portable device to assess the presence of a pulse in patients suffering from cardiac arrest in the out-of-hospital environment. The main question is how often researchers are successful in acquiring the necessary ultrasound signal in the out-of-hospital environment.

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Key information

Conditions

Cardiac Arrest, Out-Of-Hospital Cardiovascular Diseases Heart Arrest Heart Diseases Out-of-Hospital Cardiac Arrest

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Emergency Medical Service of Vienna

Vienna, 1030, Austria

About this study

In this prospective observational study, a dedicated research team will be dispatched to cardiac arrest patients treated in the prehospital environment by emergency medical services (EMS). The team will use a portable ultrasound device to identify the femoral artery and conduct a pulsed wave (PW) doppler measurement during chest compressions as well as during chest compression pauses for rhythm analysis and save the recorded images. These ultrasound pulse checks will be conducted in parallel with the normal treatment of the patient, including manual pulse checks, and will only be conducted if ultrasound is possible without interference in the resuscitation. All treatment decisions will rest with the treating EMS team.

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Out-of-hospital cardiac arrest treated by EMS
  • Minimum age of 18 years

Exclusion criteria

  • Pregnancy or suspected pregnancy
  • Disapproval of the treating EMS team
  • Adults under legal guardianship
  • Inability to perform femoral artery doppler ultrasound due to limited access to the patient and possible interference with the treating EMS team
  • Inability to perform femoral artery doppler ultrasound due to injuries or anatomic abnormalities in the femoral region or necessary emergent medical interventions in the femoral region
  • Decision to transfer the patient to the hospital with ongoing CPR for emergent procedures such as extracorporeal CPR before femoral artery doppler ultrasound could be attempted
  • Inability to safely perform femoral artery doppler ultrasound due to environmental hazards

Treatment and study plan

Point-of-care vascular ultrasound

Other

Point-of-care ultrasound will be used to image the femoral vessels and to perform a pulsed-wave doppler measurement of blood flow during chest compressions and during pauses for rhythm and manual pulse checks.

Primary outcomes

  1. Feasibility of femoral artery doppler ultrasound

    Time frame: During cardiac arrest, up to 45 minutes

    If an ultrasound image of the femoral artery of sufficient quality for Doppler ultrasound can be obtained, the primary outcome will be considered to be positive.

Secondary outcomes

  1. Time until ultrasound signal acquisition

    Time frame: During cardiac arrest, up to 45 minutes

    The time until successful acquisition of the doppler ultrasound signal will be measured in 2-minute CPR-intervals and 30-second intervals (e.g. second CPR-interval, first 30 seconds).

  2. Discordance between doppler ultrasound and manual pulse checks.

    Time frame: During cardiac arrest, up to 45 minutes

    The presence of a doppler ultrasound flow signal during rhythm analysis and the result of the manual pulse check that is performed in parallel by the treating EMS team will be evaluated and analyzed for discordance.

  3. Correlation of the result of manual pulse checks with doppler peak systolic velocity

    Time frame: During cardiac arrest, up to 45 minutes

    The correlation of the result of manual pulse checks performed by the treating EMS team with the peak systolic velocity measured by doppler ultrasound will be analyzed.

  4. Patient factors influencing probability of successful doppler ultrasound image acquisition

    Time frame: After cardiac arrest, through study completion (a maximum of 1 year)

    Patient factors sex, age, approximated bodyweight and suspected cause of cardiac arrest will be analyzed for correlation with successful doppler ultrasound image acquisition.

  5. Inter-observer variability in determining the quality of the doppler ultrasound signal.

    Time frame: After cardiac arrest, through study completion (a maximum of 1 year)

    The sonographer on site will assess the quality of the acquired doppler ultrasound images, as well as two ultrasound experts who will be blinded to the performing sonographer. The difference between these assessments will be analyzed.

Sponsors and collaborators

Lead sponsor

Medical University of Vienna

Other

Collaborators

  • Emergency Medical Service of Vienna
  • Ludwig Boltzmann Institute Digital Health and Patient Safety

Registry information

Official study title

Doppler Ultrasound Pulse Detection in Out-of-Hospital Cardiac Arrest Patients: A Feasibility Study.

Important dates

Study start
2024
Primary completion
2024
Study completion
2024
First posted
Feb 8, 2024
Registry last updated
Aug 7, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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