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NCT Number: NCT06641505

Feasibility of Deep Inspiratory Internal Jugular Vein Variability in Guiding Preoperative Fluid Replacement

Compare the incidence of hypotension during the propofol-induced period between the internal jugular vein variability-guided fluid infusion group and the conventional fluid infusion group through a fluid infusion experiment before anesthesia induction, so as to evaluate the feasibility of using the internal jugular vein variability under deep inspiration to guide preoperative fluid infusion.

Recruiting

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Key information

Age range

60 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Affiliated Hospital of University

Jiaxing, Zhejiang, China

Location status: Recruiting

Location contact

Qinghe Zhou

CONTACT

[email protected]

13732573379

About this study

Ultrasound records at least one quiet breathing cycle and one deep inhalation cycle to calculate IJVV Propofol was infused target-controlled at 4 μg/ml, and changes in arterial blood pressure within 3 minutes of propofol induction were observed.

Plan to conduct a prospective randomized controlled study to compare the incidence of hypotension during the propofol-induced period between the internal jugular vein variability-guided fluid infusion group and the conventional fluid infusion group through a fluid infusion experiment before anesthesia induction.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • age over 60 years; American Society of Anesthesiology (ASA) status Ⅱ-Ⅲ; Surgery with radial artery puncture; Propofol induction;

Exclusion criteria

  • BMI≥30kg/m2; People with short necks; Previous hypotension (systolic blood pressure <90mmHg or mean arterial pressure<65mmHg); Previous poorly controlled hypertension; Cardiac insufficiency , EF value<50%; Upper limb deep vein thrombosis; History of radiotherapy or neck surgery; Inability to maintain a supine position for necessary measurements; Mechanical ventilation status or inability to take deep breaths patients; gastrointestinal surgery; Patients allergic to propofol; Restricted fluid intake;

Treatment and study plan

Guiding rehydration

Behavioral

Preoperative fluid rehydration was performed according to 421 fluid rehydration principles

Primary outcomes

  1. The incidence of a 20% drop in blood pressure after propofol induction

    Time frame: 1 year

    The incidence of a 20% drop in blood pressure after propofol induction

Study contacts

Contact information is provided by the study sponsor or research team.

Qinghe Zhou

CONTACT

[email protected]

13732573379

Xuelian Wei

CONTACT

[email protected]

18133822661

Sponsors and collaborators

Lead sponsor

Affiliated Hospital of Jiaxing University

Other

Registry information

Official study title

Feasibility of Deep Inspiratory Internal Jugular Vein Variability in Guiding Preoperative Fluid Replacement:A Prospective, Randomized Controlled Study

Important dates

Study start
2024
Primary completion
2025
Study completion
2025
First posted
Oct 15, 2024
Registry last updated
Nov 15, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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