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NCT Number: NCT07507812

Fall Prevention in Mild Cognitive Impairment

Falls represent the leading cause of hospitalization, nursing home admissions, disability and mortality for older adults with annual healthcare costs over $50 billion. Older Veterans with cognitive impairment are at an increased risk of falls and injurious fall. The purpose of this study is to test the effects of 6 weeks of a virtual tele-neurorehabilitation intervention on fall prevention, functional mobility, strength, cognition and performance of activities of daily living. Participants will be one of 28 participants in the VA Maryland Health Care System. Participation in the study is voluntary and the research will be conducted at the VA Maryland Health Care System. The entire study will take approximately 2 years to complete. Subject's participation in the study will last 3 months.

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Key information

Age range

65 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Baltimore VA Medical Center VA Maryland Health Care System, Baltimore, MD

Baltimore, Maryland, 21201, United States

Location contact

Alyssa D Stookey, PhD MS

PRINCIPAL_INVESTIGATOR

Jamie Giffuni, MD BA

CONTACT

[email protected]

410-605-7000 ext. 4840

About this study

Falls represent the leading cause of hospitalization, nursing home admissions, disability and mortality for older adults with annual healthcare costs over $50 billion. Older Veterans with cognitive impairment are at an increased risk of falls and injurious fall. This pilot aims to determine the feasibility and effectiveness of a virtual neurorehabilitation intervention to improve functional mobility, strength, cognition and performance of activities of daily living in a cohort of 28 older Veterans with cognitive impairment. The overall goals are to improve fall risk in a population for which traditional rehabilitation programs may not be feasible. The investigators envision a neurorehabilitation model that can be readily exportable and widely implemented at other VA facilities with minimal resources as an enhancement to clinical care for fall prevention.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • community dwelling
  • at risk for falls as indicated by answering yes to one of the following: 1) have you fallen in the last year? 2) four square step test time > 15 seconds 3) are you worried about falling?
  • cognitive impairment as indicated by either 1) clinical diagnosis 2) MOCA score of 10-25
  • able to provide written consent

Exclusion criteria

  • MOCA <10 or clinically diagnosed dementia
  • inability to participate in a virtual intervention
  • serious visual or hearing problems
  • stroke with hemiparesis or severe neurological disease
  • current use of medications affecting mental state
  • current active participation in programs related to balance or mobility

Treatment and study plan

Virtual Neurophysiological Rehabilitation

Behavioral

Combining active observation (AO) and motor imagery (MI)

Primary outcomes

  1. Program Adherence

    Time frame: 6 weeks

    Number of sessions attended

Secondary outcomes

  1. Change in Four Square Step Test time

    Time frame: 6 weeks

    Time to complete the Four Square Step Test

  2. Change in 30 second chair stand test

    Time frame: 6 weeks

    Number of unassisted chair rises completed in 30 seconds

Study contacts

Contact information is provided by the study sponsor or research team.

Alyssa D Stookey, PhD MS

CONTACT

[email protected]

(410) 605-7000 ext. 5431

Odessa R Addison, PhD DPT

CONTACT

[email protected]

(410) 605-7000 ext. 5393

Sponsors and collaborators

Lead sponsor

VA Office of Research and Development

Fed

Registry information

Official study title

Fall Prevention in Cognitively Impaired Older Veterans Through Neurophysiological Rehabilitation

Acronym: NEUROFALL

Important dates

Study start
2027
Primary completion
2028
Study completion
2028
First posted
Apr 2, 2026
Registry last updated
Apr 9, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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