Factors Related to Infection Prevention After Tension-free Inguinal Hernia Repair

All of the patients received tension-free inguinal hernia repair with a mesh plug. The surgical-site infection (SSI) was diagnosed according to the criteria of the Centers for Disease Control and Prevention [5-6].

We chose cefazolin sodium and levofloxacin sodium chloride injection as peri-operative antibiotics. Cefazolin sodium is an effective antibiotic with a short plasma elimination half-life against gram-positive cocci (GPC) except for enterococci and meticillin-resistant staphylococci. It is recommended as one of the prior antibacterial agents used for clearing cuts and preventing infection in many countries including China. Levofloxacin sodium chloride injection has a wide anti-bacterial spectrum composed of gram-negative bacteria and gram-positive anaerobic bacteria including anaerobic bacteria. It can remain a high concentration in urine, so it is recommended as an attractive antibiotic for urinary tract operation [5].

In the control group, we gave normal saline as placebo by intravenous drip infusion for 30-60 min before operation. Cefazolin group and levofloxacin group received intravenous administration of cefazolin sodium 1000 mg and levofloxacin sodium chloride injection 200 mg, respectively, for 30-60 min before operation.

Inclusion criteria

• males or females aged 16-18 years old;
• no infection or hematological system disease before surgery;
• normal liver and kidney function;
• no pre-operative valvular heart disease;
• Body mass index (BMI) within 18-32.

Exclusion criteria

• fail to meet one of the inclusion criteria above;
• malignant tumor;
• history of immune system diseases;
• using or had used corticosteroids or immunosuppressants less than 1 month before surgery;
• using or had used antibiotics less than 3 d before surgery;
• pregnancy or lactation.