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Completed

NCT Number: NCT06299215

Factors and Prognosis of Obstructive Pyelonephritis Patients

Acute obstructive pyelonephritis is a condition with a high risk of complications and may require admission to the intensive care unit.

Most of the available data on this condition comes from small, retrospective, single-centre series.

To date, no large-scale study has examined the factors associated with the prognosis of patients admitted to intensive care for acute obstructive pyelonephritis.

The aim of this study is to describe the population and prognosis of patients admitted to the intensive care unit for the management of acute obstructive pyelonephritis, and to identify factors associated with a poor prognosis in these patients.

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Key information

Conditions

Pyelonephritis Acute Kidney Injury Acute Lung Injury Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Kidney Diseases Lung Diseases Lung Injury Male Urogenital Diseases Nephritis Nephritis, Interstitial Prognostic Pyelitis Renal Insufficiency Respiratory Tract Diseases Urogenital Diseases Urologic Diseases

Age range

18 year–100 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Hospital Saint Louis

Paris, 75010, France

About this study

The retrospective and multicenter study consists of a retrospective and pseudonymous collection of data from medical reports of patients treated, over the period 2015-2022, in each intensive care unit agreeing to participate, .

Investigators from each participating center will be responsible for screening on all hospitalized patients over the period 2015-2022. Patients who have been hospitalized for the management of acute obstructive pyelonephritis will be included, in the absence of non-inclusion criteria.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients over 18 years of age
  • Hospitalized in intensive care for management of acute obstructive pyelonephritis
  • Patients affiliated to a Social Security System

Exclusion criteria

  • Pregnancy
  • Opposition to data use
  • Persons under legal protection (curatorship, guardianship), legal safeguards

Treatment and study plan

Primary outcomes

  1. The primary endpoint will be a combined endpoint of death, and/or stage 3 AKI ( KDIGO classification), and/or non-recovery of renal function.

    Time frame: up to 30 days after admission to intensive care

Secondary outcomes

  1. Death

    Time frame: up to 30 days after admission to intensive care

  2. Stage 3 Acute kidney injury (KDIGO classification)

    Time frame: up to 30 days after admission to intensive care

  3. failure to recover renal function

    Time frame: up to 30 days after admission to intensive care .

    defined as creatinine levels greater than 150% of baseline value

  4. the incidence of acute renal failure defined by KDIGO 1

    Time frame: up to 30 days after admission to intensive care

  5. the incidence of acute renal failure defined by KDIGO 2 and 3

    Time frame: up to 30 days after admission to intensive care

  6. the incidence of Renal replacement therapy

    Time frame: up to 30 days after admission to intensive care

  7. the incidence of non-recovery of renal fuction

    Time frame: up to 30 days after admission to intensive care

  8. The number of days alive without Renal replacement therapy

    Time frame: up to 30 days after admission to intensive care

  9. The number of days alive without catecholamines

    Time frame: up to 30 days after admission to intensive care

  10. The number of days alive without antibiotics

    Time frame: up to 30 days after admission to intensive care

  11. The number of days alive without

    Time frame: up to 30 days after admission to intensive care

  12. Death rate

    Time frame: up to 30 days after admission to intensive care

Sponsors and collaborators

Lead sponsor

Assistance Publique - Hôpitaux de Paris

Other

Registry information

Official study title

Factors Associated With the Prognosis of Patients Admitted to for Acute Obstructive Pyelonephritis

Acronym: PYELO-OBS

Important dates

Study start
2024
Primary completion
2025
Study completion
2025
First posted
Mar 7, 2024
Registry last updated
Feb 20, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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