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NCT Number: NCT05294978

EyeConic: Qualification for Cone-Optogenetics

This study aims to prepare for the first-in-human clinical trial of cone optogenetics vision restoration. As a first step, this worldwide multicenter ocular imaging study (EyeConic Study) is performed to identify eligible patients.

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Key information

Conditions

Retinal Dystrophies Cone-Rod Dystrophies Congenital, Hereditary, and Neonatal Diseases and Abnormalities Eye Diseases Eye Diseases, Hereditary Genetic Diseases, Inborn Retinal Degeneration Retinal Diseases

Sex eligibility

All sexes

Study type

Observational

Primary location

Beijing Institute of Ophthalmology, Beijing, China

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About this study

In a subset of patients with inherited retinal dystrophies (IRDs), cones lose their light-sensitive outer segments but remain alive in a dormant stage. This creates an opportunity to resensitize them through targeted optogenetic tools. However, the true proportion of low vision patients harboring dormant, non-functional cones, is currently unknown. The worldwide multicenter retrospective study (EyeConic) aims to estimate the proportion of low vision patients with remaining cone cell bodies for the first time.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

(patients):

  • Diagnosis of generalized IRD
  • Low vision as defined as visual acuity worse or equal to 0.05 (or 20/400) in the study eye
  • Availability of macular optical coherence tomography (OCT)

Inclusion criteria

(controls):

  • Normal ophthalmic findings
  • Availability of macular optical coherence tomography (OCT)

Exclusion criteria

(all):

  • Other eye diseases with a significant effect on vision or retinal structure
  • Extraocular disease affecting retinal structure such as neurodegenerative diseases

Treatment and study plan

Optical coherence tomography (OCT)

Diagnostic Test

Data of macular optical coherence tomography (OCT)

Primary outcomes

  1. OCT - Central retinal volume

    Time frame: Baseline (about 10 minutes)

    Number of participants with preserved central retinal volume

Study contacts

Contact information is provided by the study sponsor or research team.

Lucas Janeschitz-Kriegl, MD

CONTACT

[email protected]

+41787494373

Tiana Koottungal

CONTACT

[email protected]

+41788486737

Sponsors and collaborators

Lead sponsor

Institute of Molecular and Clinical Ophthalmology Basel

Other

Registry information

Official study title

Qualification for Cone-Optogenetics (EyeConic)

Important dates

Study start
2021
Primary completion
2026
Study completion
2026
First posted
Mar 24, 2022
Registry last updated
Jul 31, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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