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Completed

NCT Number: NCT02694367

Expression of EPK in Recurrent Miscarriage

The present study is based on hypotheses that some as yet unknown genetic factors may result in recurrent miscarriage (RM). Consequently, the main aim of this study was to gain new information about the underlying genetic causes of RM in the Egyptian population and to investigate the expression of ERK and p-ERK protein in human placenta and their corresponding tissue, to assess the significance of MAPK signal pathway in progression of recurrent miscarriage and PI3K-Akt Pathway.

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Key information

Conditions

Recurrent Miscarriage Abortion, Habitual Abortion, Spontaneous Female Urogenital Diseases and Pregnancy Complications Pregnancy Complications Urogenital Diseases

Age range

20 year–40 year

Sex eligibility

Female

Study type

Observational

Primary location

Ahmed Abbas

Assiut, Cairo Governorate, 002, Egypt

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Gestational age less than 12 weeks.
  • no uterine abnormalities (examined by ultrasonography or hysterosonogram)
  • previous history of RM, defined as two or more consecutive miscarriages

Exclusion criteria

  • Gestational age 12 weeks or more.
  • Endocrine etiology like (thyroid dysfunction, and uncontrolled diabetes mellitus).
  • Antiphospholipid syndrome, inherited thrombophilias, alloimmune causes.
  • Uterine anatomic anomalies

Treatment and study plan

Investigate the MAP kinase signaling pathways through ERK and p-ERK proteins

Other

Primary outcomes

  1. The levels of ERK and AKT in placenta

    Time frame: 48 hours

Sponsors and collaborators

Lead sponsor

Assiut University

Other

Registry information

Official study title

MAP Kinase Signaling Pathways Through ERK and p-ERK Protein in Human Placenta of Women With Recurrent Miscarriage

Acronym: EPK-RM

Important dates

Study start
2015
Primary completion
2015
Study completion
2016
First posted
Feb 29, 2016
Registry last updated
Feb 29, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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