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Enrolling by Invitation

NCT Number: NCT06837779

Exposed Hypersensitive Dentin Treated With Fluoride Iontophoresis With Remineralizing Agents

The goal of this clinical trial is to learn if the application of fluoride works to treat patients suffering from dentin hypersensitivity. It will also learn about the safety of using fluoride iontophoresis with Acidulated phosphate fluoride gel.

The main questions it aims to answer are:

Does the remineralizing agent have the ability to decrease dentin sensitivity?

Researchers will compare Fluoride Iontophoresis with Acidulated Phosphate Fluoride gel , Casein phosphopeptides-Amorphus calcium phosphate (CPP-ACP), nano-hydroxyapptite (NHAP) and -active glass in decreasing dentin hypersensitivity

.

Participants will:

* Application of remineralizing agent every 3 months * Visit the dental clinic once every 3 months for checkups and tests

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Key information

Conditions

Dentin Hypersensitivity Dentin Sensitivity Stomatognathic Diseases Tooth Diseases

Age range

35 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Faculty of Dental Medicine ,Alazhar Univerisity

Cairo, Cairo Governorate, 11768, Egypt

About this study

Assess the efficacy of fluoride iontophoresis in remineralization in comparison with other ingredients.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients within 35-60 years of age.
  • Each patient has 4 or more exposed roots of posterior teeth having sensitivity.
  • Good oral hygiene.
  • Patients who will agree to the consent and will commit to the follow-up period.
  • Patients will follow instructions during study time.
  • Teeth that were vital.

Exclusion criteria

  • Patients with any systemic disease that may affect normal healing.
  • Patient with bad oral hygiene, high caries index and high plaque index
  • Patients participating in more than 1 dental study.
  • Active carious lesions.
  • Intrinsic and extrinsic stains.
  • Any previous filling of selected teeth.
  • Cracked and malformed teeth.

Treatment and study plan

Fluoride Iontophoresis with Acidulated Phosphate Fluoride

Drug

Application of fluoride gel and activated with Iontophoresis electrical pole

Remineralization with sodium fluoride varnish

Drug

CASIN PHOSPHOPEPTIDE AMORPHOUS CALCIUM PHOSPHATE

Primary outcomes

  1. Visual Analogue Scale

    Time frame: 12 months

    Measurement of sensitivity was performed after each stimulus by a Visual Analogue Scale, which consists of a 10-cm long line; the minimum value is 0 and the maximum value is 10, whether the higher scores mean worse and the lower score means better outcome.

    The patient's pain limits can suffer through an external stimulus; at 0, one end represents absence of discomfort, and the other represents severe discomfort caused by certain stimuli. Each time the patient is subjected to a stimulus, he or she is requested to point at the interval from 0 to 10, a number to correspond to the pain felt. The convenience of this type of scale is to allow demonstration of the pain intensity with absolute numbers or as a percentage of a maximum value

Sponsors and collaborators

Lead sponsor

Al-Azhar University

Other

Registry information

Official study title

Clinical Evaluation of Exposed Hypersensitive Dentin Treated With Fluoride Iontophoresis Application in Comparison With Two Different Remineralizing Agents (a Randomized Clinical Trial)

Important dates

Study start
2024
Primary completion
2025
Study completion
2025
First posted
Feb 20, 2025
Registry last updated
Feb 20, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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