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NCT Number: NCT07390084

Exploring the Decision to Drink (More) Alcohol Following Manipulations of Stress and Social Context

This preregistration documents an experiment examining the effects of acute stress and social context on alcohol-related decision-making. The study uses a 2x2 factorial design (stress vs. control × social vs. alone) with dyadic recruitment.

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Key information

Age range

21 year–50 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Washington

Seattle, Washington, 98195, United States

Location status: Recruiting

Location contact

Jonas Dora, PhD

CONTACT

[email protected]

206-741-6330

About this study

Behavioral data:

Our first set of hypotheses tests whether the decision is influenced by stress and social context:

H1a: Stress affects the decision between alcoholic and non-alcoholic drinks, so that participants in the stress conditions choose alcoholic over non-alcoholic drinks more often compared to participants in the no stress conditions.

H1b: Social context affects the decision between alcoholic and non-alcoholic drinks, so that participants in the social conditions choose alcoholic over non-alcoholic drinks more often compared to participants in the alone conditions.

H1c: We test two competing predictions:

(I) The effect of stress on the decision between alcohol and non-alcoholic drinks is modulated by social context, so that the effect of stress is stronger for participants that are in the social condition.

(II) The effect of stress on the decision between alcohol and non-alcoholic drinks is modulated by social context, so that the effect of stress is weaker for participants that are in the social condition

Drift diffusion modeling:

Our second set of hypotheses test how the decision might be influenced by stress and social context:

H2a: Stress affects the bias (but not the drift rate or boundary) parameter of the drift diffusion model, so that the bias parameter is more positive for participants in the stress conditions.

H2b: Social context affects the bias (but not the drift rate or boundary) parameter of the drift diffusion model, so that the bias parameter is more positive for participants in the social conditions.

H2c: Stress and social context have an interactive effect on the bias (but not the drift rate or boundary) parameter of the drift diffusion model, so that the bias parameter is either more or less positive for stressed participants who are in the social condition (in line with H1c).

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Drinking alcohol at least once a week
  • Consuming 4 (female) or 5 (male) drinks in one occasion at least once a month

Exclusion criteria

  • Currently pregnant or trying to become pregnant
  • Past or current treatment for alcohol use
  • Past or current medical condition that contraindicates alcohol use
  • Past or current reaction to alcohol that contraindicates alcohol use
  • Past or current medication that contraindicates alcohol use

Treatment and study plan

Stress

Other

Participants randomly assigned to the stress condition will undergo the standard protocol of the Trier Social Stress Test. Participants randomly assigned to the control condition will undergo a validated, non-stressful control procedure mirroring the TSST.

Social Context

Other

Participants randomly assigned to the social condition will make decisions about consuming alcohol with a known peer. Participants randomly assigned to the control condition will make decisions about consuming alcohol alone.

Primary outcomes

  1. Proportion of choices for alcoholic over non-alcoholic drinks.

    Time frame: 5 minutes

    Each participant will complete a two alternative forced-choice task in which they make repeated decisions between alcoholic and non-alcoholic drinks.

Study contacts

Contact information is provided by the study sponsor or research team.

Jonas Dora

CONTACT

[email protected]

2067416330

Sponsors and collaborators

Lead sponsor

University of Washington

Other

Collaborators

  • National Institute on Alcohol Abuse and Alcoholism (NIAAA)

Registry information

Acronym: DoraR00

Important dates

Study start
2026
Primary completion
2027
Study completion
2027
First posted
Feb 5, 2026
Registry last updated
Jul 24, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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