Sleep More, Stress Less: 90-Day Trial of Neuralli Mood

Neuralli Mood is a probiotic and postbiotic dietary supplement containing the proprietary gut-brain strains L. plantarum PS128 and heat-treated L. paracasei PS23. Participants take two capsules once daily, with or without food, at a consistent time for 90 days. Each two-capsule daily dose contains 30 billion CFU of L. plantarum PS128 and 20 billion heat-treated cells of L. paracasei PS23.

The study uses a prospective, open-label, single-group, within-participant design. Participants complete baseline assessments before the first dose and repeat the primary and secondary outcome assessments at the end of the 90-day supplementation period. Scheduled check-ins are used to assess adherence, tolerability, and adverse events.

The study is exploratory and is intended to generate preliminary evidence and individualized before-and-after information. Results will be interpreted in light of the absence of a concurrent control group, participant self-selection, expectation effects, and reliance on self-reported outcomes.

Inclusion criteria

• Age 18 years or older and able to provide informed consent.
• Generally healthy adult experiencing stress, occasional sleep disruption, low mood, anxiety symptoms, or work-related burnout.
• Willing and able to take two capsules of Neuralli Mood daily for 90 days.
• Willing and able to complete electronic baseline, follow-up, adherence, and safety assessments.
• Has reliable access to the internet and an email-enabled device.

Exclusion criteria

• Pregnant or nursing.
• Known allergy or hypersensitivity to Neuralli Mood, probiotics, or any product ingredient.
• Severe or unstable gastrointestinal disease, including a condition for which probiotic use may be inappropriate.
• Immunocompromised status or current immunosuppressive therapy.
• Severe or unstable mood disorder, acute psychiatric symptoms, or a current risk of harm to self or others.
• A clinically significant sleep disorder for which participation or changes in symptoms should be managed by a healthcare professional.
• Cognitive impairment or another condition that prevents informed consent or reliable completion of study procedures.
• History of a severe allergic reaction when the investigator determines probiotic use may present an unacceptable risk.
• Use of a medication or presence of a medical condition for which a healthcare professional advises against probiotic supplementation.
• Any other circumstance that, in the investigator's judgment, makes participation inappropriate or unsafe.