Explore the Clinical Application Value of Ciprofol in Painless Colonoscopy

Subjects were randomly assigned 1:1 to receive intravenous ciprofol or propofol 1 hour prior to diagnosis and treatment. A centralized random grouping method was used in this study. After screening subjects, the researchers in each test center will log in to the random system after being confirmed by the researchers of the center, fill in the screening information, obtain the random number information, and issue the corresponding study drugs according to the random number. Random shelter number was generated by SAS software, and was used as the total blind base pair drug number and imported into the centralized random grouping system. In this study, evaluation researchers and drug administration researchers were set up. The whole process of the experiment was blind not only to the subjects, but also to the evaluation researchers. Evaluation investigators and administration investigators were set up in this study. The administration investigators were only involved in the process of random grouping, drug dispensing and administration, and the other processes including informed consent of subjects, screening, evaluation of efficacy indicators and safety, and planned visits were all completed by the evaluation investigators.

Inclusion criteria

• Patients undergoing painless colonoscopy;
• Patients aged from 18 to 80 years old, no gender limitation; 3, 18 < BMI < 30kg/m2 [BMI = weight (kg)/ height (m) squared]

• American Society of Anesthesiologists (ASA) grades ⅰ ~ ⅲ

Exclusion criteria

• Preoperative blood pressure >160/100 mmHG or < 80/50 mmHG.
• Preoperative ecg suggested heart rate <50 times/min;
• Acute respiratory tract infection with no cured history within 2 weeks;
• People with serious metabolic diseases such as heart, brain, lung, liver, kidney and diabetes;
• Predict people who may have or have had difficult airway;
• Patients with obvious electrolyte disorders such as hyperkalemia;
• Long-term use of immunosuppressants such as hormones or history of adrenocortical inhibition;
• People who are known to be allergic to emulsions and opioids;
• Preoperative combined use of other sedative and analgesic drugs
• Suspected abuse of narcotic analgesics or sedatives; 11, there are neuromuscular system diseases, mental diseases and other people do not cooperate with the communication;